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Review article: Biomedical intelligence

Vol. 141 No. 1516 (2011)

Life extension: a biomedical goal?

  • G Barazzetti
  • M Reichlin
DOI
https://doi.org/10.4414/smw.2011.13181
Cite this as:
Swiss Med Wkly. 2011;141:w13181
Published
11.04.2011

Summary

The potential for development of biomedical technologies capable of extending the human lifespan raises at least two kinds of question that it is important both to distinguish and to connect with one another: scientific, factual questions regarding the feasibility of life extension interventions; and questions concerning the ethical issues related to the extension of life- and healthspans. This paper provides an account of some life extension interventions considered to be amongst the most promising, and presents the ethical questions raised by the prospect of their pursuit. It is suggested that problems concerning the effects of these technologies on health care resources and on intergenerational relationships will be the most difficult to tackle.

References

  1. Wilmoth JR. Demography of longevity: past, present, and future trends. Exp Gerontol. 2000;35:1111–9.
  2. Orman A. The epidemiological transition. Milbank Memorial Fund Quart. 1971;49:509–38.
  3. Wilmoth JR. In search of limits. In: Watcher KW, Finch CE, eds. Between Zeus and Salmon: the Biodemography of Longevity. Washington D.C.: National Academy Press; 1997. pp. 38–64.
  4. Christensen K, Vaupel JW. Determinants of longevity: genetic, environmental and medical factors. J Intern Med. 1996;240:333–41.
  5. Horiuchi S. Greater lifetime expectations. Nature. 2000;405:744–45.
  6. Tuljapurkar S, Li N, Boe C. A universal pattern of mortality decline in the G7 countries. Science. 2000;405:789–92.
  7. Richel T. Will human life expectancy quadruple in the next hundred years? Sixty gerontologists say public debate on life-extension is necessary. J Anti-Aging Med. 2003;6:309–14.
  8. Turner L. Life extension technologies: economic, psychological, and social considerations. HEC Forum. 2003;15:258–73.
  9. de Grey ADNJ, Ames BN, Andersen JK, Bartke A, Campisi J, et al. Time to talk SENS: Critiquing the immutability of human aging. Ann NY Acad Sci. 2002;959:452–62.
  10. Warner H, Anderson J, Austad S, et al. Science fact and the SENS agenda. What can we reasonably expect from aging research? EMBO Reports 2005;6:1006–8.
  11. Mykytyn CE. Anti-aging medicine: predictions, moral obligations, and biomedical intervention. Anthropol Quart. 2006;79:5–31.
  12. Klatz R. New horizons for the clinical speciality of anti-aging medicine. The future with biomedical technologies. Ann NY Acad Sci. 2005;1057:536–44.
  13. Stuckelberger A. Anti-ageing medicine: myths and chances. Zürich: TA-SWISS, vdf Hochschulverlag AG an der ETH Zürich; 2008.
  14. Binstock RH. Anti-aging medicine and research: a realm of conflict and profound societal implications. J Gerontol Series A: Biol Sci Med Sci. 2004;59, 523–33.
  15. Anton B, Vitetta L, Cortizo F, Sali A. Can we delay aging? The biology and science of aging. Ann NY Acad Sci. 2005;1057:525–35.
  16. Kirkwood TBL. Time of our lives: the science of human aging. Oxford: Oxford University Press; 1999.
  17. Kirkwood TBL, Austad, SN. Why do we age? Nature. 2000;408:233–38.
  18. Kirkwood TBL. Where will it all end? Lancet. 2001;357:576.
  19. Balcombe NR, Sinclair A. Ageing: definitions, mechanisms and the magnitude of the problem. Best Pract Res Clin Gastroenterol. 2001;15:835–49.
  20. Hayflick L. How and why we age. Exp Gerontol. 1998;33:639–53.
  21. Hayflick L. The future of ageing. Nature. 2000;408:267–9.
  22. Caplan AL. An unnatural process: Why it is not inherently wrong to seek a cure for aging. In: Post SG, Binstock RH, eds. The Fountain of Youth. Cultural, Scientific, and Ethical Perspectives on a Biomedical Goal. Oxford: Oxford University Press; 2004. p. 271–85.
  23. Rose MR, Graves JL. What evolutionary biology can do for gerontology. J Gerontol. 1989;44:B27–B29.
  24. Kirkwood TBL, Rose MR. Evolution of senescence: late survival sacrificed for reproduction. Phil Trans Roy Soc Med. 1991;332:15–24.
  25. Masoro EJ, Austad SN. The evolution of anti-aging action of dietary restriction: a hypothesis. J Gerontol Series A: Biol Sci Med Sci. 1996;51:B387–B391.
  26. Arking R. Extending human longevity: A biological probability. In: Post SG, Binstock RH, eds. The Fountain of Youth. Cultural, Scientific, and Ethical Perspectives on a Biomedical Goal. Oxford: Oxford University Press; 2004. p. 177–200.
  27. Ramsey JJ, Colmana RJ, Binkleya NC, Christensena JD, Gresla TA, et al. Dietary restriction and aging in rhesus monkeys: the University of Wisconsin study. Exp Gerontol. 2000;35:1131–49.
  28. Zainai TA, Oberley TD, Allison DB, Sweda LI, Weindruch R. Caloric restriction of rhesus monkeys lowers oxidative damage in skeletal muscle. FASEB J. 2000;14:1825–36.
  29. Roth GS, Lesnikov V, Lesnikov M, Ingram DK, Lane M. Dietary caloric restriction prevents the age-related decline in plasma melatonin levels of Rhesus monkeys. J Clin Endocrinol Metab. 2001;86:3292–5.
  30. Roth GS, Lane MA, Ingram DK, Mattison JA, Elahi D, et al. Biomarkers of caloric restriction may predict longevity in humans. Science. 2002;297:811.
  31. Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, et al. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science. 2009;325:201–4.
  32. Nikolich-Zugich J, Messaoudi I. Mice and flies and monkeys too: Caloric restriction rejuvenates the aging immune system of non-human primates. Exp Gerontol. 2005;40:884–93.
  33. Hursting SD, Lavigne JA, Berrigan D, Perkins SN, Barrett JC. Calorie restriction, aging, and cancer prevention: mechanisms of action and applicability to humans. Ann Rev Med. 2003;54:131–52.
  34. Weyer C, Walford RL, Harper IT, Milner M, MacCallum T, et al. Energy metabolism after 2 y of energy restriction: the Biosphere 2 experiment. Am J Clin Nutr. 2000;72:946–53.
  35. Holloszy JO, Fontana L. Caloric restriction in humans. Exp Gerontol. 2007;42:709–12.
  36. Dirks AJ, Leeuwenburgh C. Caloric restriction in humans: Potential pitfalls and health concerns. Mech Aging Develop. 2006;127:1–7.
  37. Fontana L, Partridge L, Longo VD. Extending healthy life span – from yeast to humans. Science. 2010;328:321–6.
  38. Spindler SR, Dhahbi JD, Mote PL, Kim HJ, Tsuchiya T. Rapid identification of candidate CR mimetics using microarray [abstract]. Biogerontol. 2003;4(suppl. 1):89.
  39. Ingram DK, Anson RM, de Cabo R, Mamczarz J, Zhu M, Mattison J, et al. Development of calorie restriction mimetics as a prolongevity strategy. Ann NY Acad Sci. 2004;1019:412–23.
  40. Lamberts SWJ, van den Beld AW, van der Lely A. The endocrinology of aging. Science. 1997;278:419–24.
  41. Rudman D, Feller AG, Nagraj HS, et al. Effects of human growth hormone in men over 60 years old. NEJM. 1990;323:1–6.
  42. Vance ML. Can growth hormone prevent aging? NEJM. 2003;348:779–80.
  43. Corpas E, Harman SM, Blackman MR. Human growth hormone and human aging. Endocr Rev. 1993;14:20–39.
  44. Olshansky SJ, Hayflick L, Carnes BA. Position statement on human aging. J Gerontol Series A: Biol Sci Med Sci. 2002;57A, B292–B297.
  45. Bartke, A, Coschignano, K, Kopchick, J, Chandrashekar, V, Mattison, J, Kinney, B, Hauk, S. Genes that prolong life: relationships of growth hormone and growth to aging and lifespan. J Gerontol Series A: Biol Sci Med Sci. 2001;56:B340–B349.
  46. Laron Z. Do deficiencies in growth hormone and insulin-like growth factor-1 (IGF-1) shorten or prolong longevity? Mech Aging Develop. 2004;126:305–07.
  47. Kann PH. Growth hormone in anti-aging medicine: a critical review. Aging Male. 2003;6:257–63.
  48. Arking R, Burde V, Graves K, Hari R, Soliman S, et al. Selection for longevity specifically alters antioxidant gene expression and oxidative damage patterns in Drosophila. Exp Gerontol. 2000;35:167–85.
  49. Melov S, Ravenscroft J, Malik S, Gill MS, Walker DW, et al. Extension of life-span with superoxide dismutase/catalase mimetics. Science. 2000;289:1567–9.
  50. Kang HL, Benzer S, Min KT. Life-extension in Drosophila by feeding a drug. Proc Nati Acad Sci USA. 2002;99:838–43.
  51. Larsen PL, Clarke CF. Extension of lifespan in Caenorhabditis elegans by a diet lacking coenzyme Q. Science. 2002;295:120–3.
  52. Djojosubroto MW, Choi YS, Lee HW, Rudolph KL. Telomeres and telomerase in aging, regeneration and cancer. Molec Cells. 2003;15:164–75.
  53. Harman D. Aging: overview. Ann NY Acad Sci. 2001;928:1–21.
  54. Wright WE, Brasiskyte D, Piatyszek MA, Shay JW. Experimental elongation of telomeres extends the lifespan of immortal x normal cell hybrids. EMBO J. 1996;15:1734–41.
  55. Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, et al. Extension of life-span by introduction of telomerase into normal human cells. Science. 1998;279:47–59.
  56. Geserick C, Blasco MA. Novel roles for telomere in aging. Mech Aging Develop. 2006;127:579–83.
  57. Lafontaine C. La société postmortelle. La mort, l’individu et le lien social à l’ère des technosciences. Paris: Editions du Seuil; 2008.
  58. Callahan D. What Kind of Life? The Limits of Medical Progress. New York: Simon & Schuster; 1990.
  59. Chapman AR. The social and justice implications of extending the human lifespan. In: Post SG, Binstock RH, eds. The Fountain of Youth. Cultural, Scientific, and Ethical Perspectives on a Biomedical Goal. Oxford: Oxford University Press; 2004. p. 340–61.
  60. Harris J. A response to Walter Glannon. Bioethics. 2002;16:284–91.
  61. Harris J. Enhancing Evolution: The Ethical Case for Making Better People. Princeton: Princeton University Press; 2007.
  62. Macklin R. Global Health. In: Steinbock B, ed. The Oxford Handbook of Bioethics. Oxford: Oxford University Press; 2007. p. 696–720.
  63. de Grey ADNJ. The foreseeability of real anti-aging medicine: focusing the debate. Exp Gerontol. 2003;38:927–34.
  64. Maienschein J, Sunderland M, Ankeny RA, Robert JS. The ethos and ethics of translational research. Am J Bioethics. 2008;8(3):43–51.