DOI: https://doi.org/10.4414/smw.2013.13782
The Swiss Academy of Medical Sciences (SAMS) helpfully pointed out that one of our claims about the “whole brain” approach for donation after cardiac arrest requires clarification. Drawing on data from resuscitation research, we argue that a loss of brain function may not be irreversible after ten minutes of cardiac arrest. However, these data only provide limited evidence for our claim. First, the cardiac activity of the patients in the cited resuscitation studies was not assessed by means of transthoracic echocardiography. It is therefore possible that they had residual cardiac and circulatory function prior to being resuscitated. Second, investigators did not perform a neurological exam before initiating their resuscitation.
For both reasons, it is not clear that the evidence from resuscitation studies can be extrapolated to patients who fulfil the SAMS criteria for diagnosing death after permanent cardiac arrest – namely 1) the documented absence of cardiac activity and 2) a clinical diagnosis of “whole brain” death after a stand-off period of at least 10 minutes without resuscitation measures. However, while acknowledging this limitation, we submit that there is no direct evidence to either support or refute the “whole brain” death approach for donation after cardiac arrest. In our view the data from resuscitation research, although clearly non-ideal, can and should be considered in evaluating the SAMS guidelines for determining death in the context of organ transplantation.
1 Monteverde S, Rid A. Controversies in the determination of death: perspectives from Switzerland. Swiss Med Wkly. 2012;142:w13667 http://www.smw.ch/content/smw-2012-13667/ .