Host response to fungal infections – how immunology and host genetics could help to identify and treat patients at risk

The authors review the most important genetic and immunological factors that influence human susceptibility to Candida and Aspergillus infections and discuss the potential role of basic research to promote precision medicine for infectious diseases. We discuss how immunogenetic studies can help to provide tools for improved identification of high-risk patients and the development of tailored antifungal therapies.

When membranes need an ESCRT: endosomal sorting and membrane remodelling in health and disease

Originally discovered as regulators of cargo sorting during endosomal trafficking, ESCRT (endosomal sorting complexes required for transport) proteins are emerging as flexible machines that shape the behaviour of membranes throughout the cell.

Staphylococcus aureus and methicillin resistance in Switzerland: regional differences and trends from 2004 to 2014

The proportion of MRSA among S. aureus isolates in Switzerland decreased overall from 2004 to 2014. Worrisome increases of NmMRSA were found in younger persons and outpatients.