What is finally responsible for neurodegeneration in human patients with Alzheimer’s disease? We need continuing research into all possible causes of Alzheimer’s disease to find a cure for this disease.
The number of studies addressing mesenchymal stem cell (MSC) biology and their capacity to treat a broad range of human diseases at the preclinical and clinical level has grown exponentially in the last two decades, with often confusing and conflicting results.
Many antimicrobial stewardship programmes (ASPs) target the intensive care unit owing to high antimicrobial utilisation. This review summarises and assesses the quality of evidence supporting the implementation of various ASP strategies in the intensive care unit setting.
Targeting of oncogenic driver mutations with small-molecule inhibitors resulted in powerful treatment options for cancer patients in recent years.
This review summarises the current knowledge on the role of crucial pathways driving prostate cancer progression as well as metastatic disease and discusses the potential use of novel specific target molecules and how it can be exploited to avoid overtreatment and increase quality of life.
Low antituberculosis serum drug levels have been associated with poor tuberculosis treatment outcome, therefore therapeutic drug monitoring could be an important tool to guide tuberculosis treatment in case of treatment failure or late treatment response.
Obesity may, counterintuitively, be protective and associated with greater survival in certain groups of people, such as the very elderly or those with certain chronic diseases – the “obesity paradox”.
A unique feature of the olfactory system is the dual role of the odorant receptor: it does detect odours in the olfactory epithelium but it also contributes to neuronal circuit formation in the olfactory bulb.
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