Original article

Uncertain progress in Swiss perioperative mortality 1998–2014 for 22 operation groups

DOI: https://doi.org/10.4414/smw.2019.20034
Publication Date: 24.03.2019
Swiss Med Wkly. 2019;149:w20034

Wacker Johannesa, Zwahlen Marcelb

a Institute of Anaesthesia and Intensive Care, Hirslanden Clinic, Zurich, Switzerland

b Institute of Social and Preventive Medicine (ISPM), University of Bern, Switzerland



The perioperative mortality rate (POMR) is used as a quality indicator to monitor health care system performance at regional and national levels. The Swiss Federal Office of Public Health publishes national in-hospital mortality rates for several indicator conditions and indicator operation types (IORs). We investigated long-term time trends of POMRs from 1998–2014. In view of continual advances in perioperative care, we expected to find decreasing trends.


Non-cardiosurgical IORs containing aggregated age- and sex-specific data (number of operations and deaths) for all years of the study period were included to calculate age-standardised POMRs using the 2013 European Standard Population. We assessed calendar time trends of POMRs using multivariable Poisson regression. We categorised IORs according to the type of time trend (decreasing, unchanged, or increasing incident rate ratio) and mean risk levels (age-adjusted POMR).


A total of 22 IORs were included, comprising 1,561,012 operations and 22,140 deaths (overall crude POMR 1.42%). POMR trends decreased for 6 IORs representing 26.8% of operations, remained unchanged for 13 IORs (56.9% of operations), and increased for 3 IORs (16.4% of operations). IOR categorisation according to POMR trends and to risk levels yielded four groups. (1) Decreasing POMR trends, low- to intermediate-risk IORs (age-adjusted POMR 0.2–2.2%): cholecystectomy; arterial pelvic/leg aneurysm or dissection operation; femoral neck fracture; trochanteric fractures; gastric, duodenal or jejunal ulcer resection; major pulmonary or bronchial resection. (2) Unchanged POMR trends, low-risk IORs (0.1–0.9%): transurethral resection of the prostate (TUR prostate); hernia repair without intestinal operation; hysterectomy; extracranial vascular operation; nephrectomy; amputation foot, non-traumatic. (3) Unchanged POMR trends, intermediate-risk IORs (1.7–3.8%): hernia repair with intestinal operation; gastric carcinoma resection; non-ruptured abdominal aortic aneurysm (open operation); arterial pelvic/leg thromboembolic operation; colorectal resection, pancreatic resection; complex oesophageal procedure. (4) Increasing POMR trends, low- to high-risk IORs (0.1–5.2%): hip endoprosthesis; cystectomy; amputation lower limb. Impact of sex on POMR: hysterectomy and TUR prostate comprised 19.7% of all operations; among the remaining operations, 68.5% showed significantly lower and 27.1% significantly higher POMRs in females. 4.4% showed no sex difference.


In Switzerland, in-hospital POMR trends from 1998–2014 were unchanged or even increasing for the majority of IORs (73% of included operations). Our analysis used age-standardisation but cannot account for changes in coding practices and organisation of healthcare delivery. POMR trends should be systematically monitored at the national level and used to guide priorities in national quality improvement strategies.

Keywords: perioperative mortality rate, time-trend analysis, surgical mortality, surgical complications, Switzerland


Perioperative mortality rates (POMRs) are increasingly used as indicators of perioperative safety and quality at the regional and national levels of healthcare [14]. POMRs are usually reported as in-hospital or 30-day mortality rates, and are recommended by the World Health Organization [5] and the Lancet Commission on Global Surgery [6, 7] as core health indicators. POMRs that are based on routinely collected mortality data help to monitor system performance [1], to identify opportunities for improvement and to assess the overall effects of quality and safety interventions [8]. Studies have documented a substantial level of surgical in-hospital mortality (European average: 4%) [9]. This may be related, in part, to adverse events, which can affect up to 30% of surgical patients [10, 11]. More than 50% of such adverse events have been estimated to be preventable [12], which indicates room for quality improvement.

In Switzerland, the Federal Office of Public Health (FOPH) publishes national in-hospital mortality rates (CH-IQI) for a number of indicator conditions and procedures [13], whereas national data about complications and adverse events are limited [14]. Estimates of preventable patient harm and the strategies promoted to improve safety and quality in Switzerland [15] are often based on international literature [16, 17]. From a public health perspective, it is important to know the POMR trends for defined surgical populations, such as patients undergoing procedures belonging to the field of nationwide planned highly specialised medicine (HSM) [18]. Such trends are not a measure of overall perioperative quality, but they may help to identify defined surgical patient groups deviating from expected outcomes, to generate hypotheses about potentially modifiable risk factors and to set priorities for further investigations and the development of public health interventions at the national level.

Based on the general advances in perioperative care, an overall tendency of decreasing POMR trends should be expected. To our knowledge, national mortality trends for defined surgical populations based on the CH-IQI data have not been published to date. Therefore, we calculated and analysed such trends after age-standardisation of POMRs for different years for suitable surgical patient groups using the routine data published by the FOPH. By formally testing the hypothesis that long-term time trends of POMRs are generally decreasing, we investigated whether the trends of age-standardised POMRs for selected IORs were constant, increasing, or decreasing over the study period.

Materials and methods

In line with Swiss federal law, the FOPH publishes freely accessible in-hospital mortality data on the internet for a number of medical indicator conditions and surgical indicator procedures (CH-IQI) [13]. We based this study on data that are freely accessible on the websites of the Swiss FOPH. We described time trends of POMRs after direct age standardisation using the European Standard Population [19]. In a second step, multivariable Poisson regression was used to formally analyse time trends of mortality rates while adjusting for age and sex distribution [20, 21].

Data sources

Data collection pathway

Swiss hospitals are legally bound by the Federal Statistics Act of 1992 (BStatG) and the Federal Act on Health Insurance of 1996 (KVG) to report administrative and medical data (including in-hospital deaths, main diagnoses and main procedures) necessary for the publication of the medical statistics of hospitals (“Medizinische Statistik der Krankenhäuser”) by the Federal Statistical Office [22]. Mortality always defines a case as an “inpatient” hospital stay [22]. Data are transferred from hospitals to the Cantonal Statistical Offices, from there to the Federal Statistical Office and to the FOPH [13] (see appendix 1 for detailed description).

Swiss inpatient quality indicators (CH-IQIs) published by the Federal Office of Public Health [23]

The FOPH publishes CH-IQIs for 49 selected indicator disease patterns and procedures. Depending on the clinical field, some CH-IQIs include information about case numbers, information about proportions (e.g., share of stroke patients treated in a stroke unit), special features (e.g., length of stay), or age- and sex-specific mortality [13]. In 2014, the CH-IQIs covered 46% of all inpatient cases and 63% of inpatient deaths [13]. CH-IQIs are published on a freely accessible website and present mortality as both indicator-specific mortality and as standardised mortality ratios (SMR) for individual hospitals [13, 23]. SMRs are calculated using indirect standardisation and age- and sex-adjustment as the ratio of observed deaths divided by the expected deaths for a given indicator, where the expected deaths is calculated as the number of indicator cases in the hospital multiplied by the nationwide age- and sex-adjusted mortality rate for the indicator (nationwide deaths divided by nationwide cases) [13]. SMRs can be compared for different indicators and hospitals using an internet tool [23]. The nationwide reference data are published separately as downloadable “.zip” files containing data in “.txt” format for each indicator [24, 25]. The 2013 data set contains data from 1998–2013 [24], and the 2014 data set contains data from 2004–2014 [25]. Data from 2004–2013 are overlapping in the two sets (for data checks, see below). The “.txt” file names contain the description and definition of the indicator according to the CH-IQI nomenclature [13, 24, 25]. For the purpose of the current analysis, these reference data sets were used. The observations in such data sets include information on calendar year, age group, sex, number of deaths per age group, number of cases (operations) per age group, and mortality rate (deaths/cases) per age group.

Selection of indicator operations (IORs)

Rationale for the inclusion of indicators

The study period was defined as the years 1998–2014 based on (1) the earliest availability of data, and (2) start of the research project in 2015/2016 (at this time, data were available until 2014). During the 17-year study period, new indicators were added by the FOPH, and the specifications for calculating the data are constantly revised [13, 26]. For the purposes of this analysis it was therefore important to choose indicators that (1) were present in both data sets used (see data sources 2013/2014, above), (2) contained data for all years of the study period, and (3) had their results calculated with the same specification version (V4 [26]).

Clinical considerations
  1. From the various information contained in the CH-IQIs [13], only indicators containing data regarding age- and sex-specific mortality were included.
  2. Clinical setting: surgical patients usually share typical care pathways, including preoperative assessment, anaesthesia care, OR and (often) postoperative facilities (postanaesthesia care units, intensive care units) [9]. Due to these common features of surgical patients, those undergoing nonsurgical invasive procedures or interventions and conservative medical management were not included in the study.
  3. Noncardiac surgery: because of their separate and specific perioperative pathways [9] and in line with other studies [9, 27, 28], cardiosurgical procedures were not included.
  4. Overall indicators: some FOPH indicators summarise mortality data for a group of multiple operations related to a surgical area (e.g., “colorectal resections”). If available, such overall indicators were included instead of indicators describing one specific operation within the overall surgical group (e.g., “colorectal resections for bowel ischaemia”).
Highly specialised medicine defined by the Swiss Conference of Cantonal Health Directors

In Switzerland, highly specialised medicine (HSM, including medical fields and interventions) is characterised by the following criteria: rarity, high potential for innovation, high personnel or technical costs, or complex treatment procedures [18]. In contrast to other fields of healthcare that are organised in Switzerland by the individual cantons, HSM is planned by the Swiss Conference of Cantonal Health Directors (GDK) on a nationwide level with the objective to concentrate such services in order to improve quality of care and to optimise efficiency [29]. Because of the relevance of HSM for this analysis of nationwide mortality data, HSM fields were reviewed in view of overlaps with the selected IORs [30, 31]. The only HSM field found to be relevant for this analysis was the field of complex highly specialised visceral surgery [30, 31]. In this field, procedure groups that overlapped with IORs fulfilling the inclusion criteria were pancreatic resections, oesophageal resections and low resection of the rectum. The latter constitutes a part of the IOR group “colorectal resections”, but cannot be separated within the FOPH data [31]. As complex and highly specialised visceral surgery had been assigned to HSM in 2013, the current analysis (1998–2014) may not capture trend-relevant effects of HSM-related interventions.

Inclusion and exclusion criteria

Based on these considerations, indicators were included if they met all of the following criteria: (1) were available in both the 2014 and 2013 FOPH data sets; (2) contained data for all years studied (1998–2014); (3) were calculated using the same specification version in all data sets (V4 [26]); (4) contained data about age- and sex-specific mortality; (5) contained data about a surgical operative procedure; (6) contained data about a non-cardiosurgical procedure; /7) contained data about an overall indicator of a surgical area or of a specific surgical operation subgroup if no overall indicator was available.

Indicators were excluded from the analysis if they met one or more exclusion criteria: (1) were not contained in the 2014 and 2013 FOPH data sets; (2) did not contain data for all years studied (1998–2014); (3) had not been calculated using the same specifications (V4 [26]) in all data sets; (4) contained no data about age- and sex-specific mortality; (5) contained no data about a surgical operative procedure (in contrast to nonsurgical procedures or conservative management); (6) contained data about a cardiosurgical (in contrast to non-cardiosurgical) procedure; (7) contained no data about an overall indicator of a surgical area (unless no overall indicator was available).

The inclusion and exclusion criteria were checked in an Excel spreadsheet using the indicator definitions in the .txt files for individual IORs.

Ethical considerations

All data used for this analysis are anonymised and open access. Their use for review, reanalysis and re-interpretation is not expected to pose ethical problems.

Data import, clearance, preparation of files and variables

The “.zip” files containing the 2013 and 2014 datasets were downloaded from the FOPH website [24, 25]. From “.txt” files for each IOR, data were imported using the Stata command “import delimited” [32]. Data for 1998–2003 were imported from the 2013 set, and data for 2004–2014 from the 2014 set (for the FOPH data structure see above; for data checks of the overlapping data and exceptions see below). Notably, age groups with no cases (stratum population = 0) are omitted in the FOPH data sets [24, 25]. However, from the data collection process and the presentation on the FOPH website, it is clear that such observations are not “missing values” but are observations for which no cases have been reported according to the regular process (“omitted” rather than “missing” observations [33]). As the data analysis required complete age groups, missing groups were reconstructed (“rectangularised”) [34] to show zero counts for files with these missing age groups (for details, see appendix 1).

Direct standardisation using the 2013 European Standard Population

Direct standardisation

Direct standardisation produces a set of standardised rates by applying the age–sex specific rates from the study populations to a standard population [35]. In contrast to indirect standardisation, direct standardisation gives more accurate results in the case of small numbers of events in any of the age–sex groups of the population [35]. This method was chosen because the annual IOR populations compared in this analysis are independent populations, and the number of events (deaths) is relatively small (in the range of several percent). Directly standardised POMRs were calculated using the Stata command “distrate” [36, 37], which calculates the standardised rates and their 95% confidence intervals (CIs). To calculate the 95% CIs, we used the method proposed by Dobson, Kuulasmaa [38] and implemented in the “distrate” command [37]. For each IOR, we graphically show the overall crude and age-adjusted POMR and 95% boundaries [39, 40]. As a standard population, the 2013 European Standard Population (ESP) [19] was used after minimal adaptation to the FOPH groups (see appendix 1 for detailed description).

Parameters for presentation of results
  1. Sex versus gender
  2. The FOPH data set contained a few sporadic cases of male hysterectomy and female transurethral resection of the prostate (TUR prostate), but it was not evident whether these represented correct entries for patients with differing genetic sex and gender (e.g., gender reassignment surgery [41], or TUR prostate after gender reassignment surgery [42]) or were erroneous entries. Therefore, sex- or gender-specific time trends were not included in this analysis for TUR prostate or hysterectomy cases.
  3. Classification of POMR levels
  4. The classification of POMR levels was chosen in analogy to established definitions used for the classification of surgical risk of major adverse cardiac events (MACE). Low risk: estimated 30-day cardiac event rates (cardiac death and myocardial infarction) of <1% [43]; elevated risk: ≥1% [44]; intermediate risk: 1–5% [43]; high risk: >5% [43, 45, 46]; extremely high risk: >20% [45, 46].
  5. Reporting format for POMR
  6. As is often the case in clinical literature, perioperative mortality rates were reported as percentages of the corresponding populations, and over a defined time period [9, 10, 4750].

Time trend analysis using Poisson regression

Poisson regression

Poisson regression can be used to examine how incident rates [20] differ between groups of people or between different exposure levels by estimating the incident rate ratios adjusted for possible differences in age and sex distributions [20, 51]. Multivariable Poisson regression was used to formally assess how, for each IOR, POMR changed over calendar time [51]. “Total number of deaths” was used as the outcome variable, “year” as independent variable and “pop” (the total number of operations) as offset in the regression equation. Rather than assuming a linear relationship between calendar year and the log POMR over the entire study period of 17 years (1998–2014), we generated three consecutive time intervals based on tertiles of time [52]. The first interval comprised the years 1998–2003 (6 years), the second comprised the years 2004–2009 (6 years), and the third comprised the years 2010–2014 (5 years). In the first step, the first interval served as reference time period, with which the second and third intervals were compared. In a second analysis, we compared the early and the late period to the middle period. In a third step, sex-specific analyses of the age-adjusted effect of time on POMRs were performed. All steps of the Poisson regression were first completed for crude POMRs, and then for age- and sex-adjusted POMRs. We report the regression results as incident rate ratios (IRRs) with 95% confidence intervals (CIs) [51, 53, 54].

Categorisation and ranking of results

Presentation of the results was determined after initial post hoc exploration of the findings. Ranking was achieved by sorting the IORs using Stata by (1) the age-adjusted POMR time-trend direction (Poisson-regression [20, 51] results for IRR of time interval 3 compared with interval 2 – decreasing, unchanged, or increasing [21]) over the study period of 17 years, and (2) by incremental average directly age-adjusted [36, 37] POMR levels (risk levels) over the entire study period. The IRR of the late time interval 3 compared with time interval 2 was favoured as a ranking criterion over the IRR of time interval 2 compared to the early time interval 1, because the later time intervals appear more relevant for current developments in the perioperative setting.

Check of data completeness

For the included IORs, the .txt files for both the 2013 and 2014 data sets were visually checked. In addition, the data overlapping both data sets (for the years 2004–2013) were checked for consistency by subtracting the corresponding data sets from one another in Excel, and these were accepted if the result was 0. Inconsistencies and missing data in the 2014 data set were found for IOR “G.3.1. hysterectomy”. In view of this inconsistency, only the data from the 2013 data set were used for the analysis except the regularly included data for the year 2014.


The following software was used: Data import – TextEdit® version 1.12 (329) Copyright© 1995–2016 Apple Inc., Cupertino, CA, U.S.; Microsoft Excel® for Mac, version 16.15 (180709) Copyright© 2018 Microsoft Corp., Redmond, WA, U.S.; Adobe Acrobat Reader DC, Continuous Release, version 2018.011.20055, Copyright© 2003–2017 Solid Documents Limited, Nelson NZ; Preview Version 9.0 (909.18) Copyright© 2002–2016 Apple Inc. Data analysis: Stata/IC 14.2 for Mac, Copyright© 1985–2015 StataCorp LLC, College Station, TX, U.S. Manuscript preparation: Microsoft Word® for Mac, version 16.15 (180709) Copyright© 2018 Microsoft Corp. Literature references: EndNote™ X8.2, Clarivate Analytics, Philadelphia, PA, U.S.


Detailed results are given in figures 1–4, and table 2 and table 3.

Indicator selection

The FOPH CH-IQI comprised 347 indicators in 2014. Based on the inclusion and exclusion criteria, 325 indicators could not be included: 232 indicators contained no data about age-and sex-specific mortality; 14 indicators contained data about cardiosurgical procedures; 47 indicators contained data about nonsurgical procedures/conditions; 16 indicators contained data about a surgical subgroup (when an overall indicator was available); and 16 indicators did not contain data for all years studied (1998–2014). Thus, 22 indicators were included in the analysis (table 1).

Table 1

Indicator operations (IOR) used by the Federal Office of Public Health (FOPH) and selected for time trend analysis.

Selected indicator operationsOriginal German FOPH indicator nameFOPH indicator codeCases 1998–2014% (all)Deaths 1998–2014Crude POMR (%)
Cholecystectomy (no tumour)Cholezystektomie bei Gallensteinen und Cholezystitis, ohne Tumor, MortalitätE.1.1.M18366711.84590.2
Arterial pelvic or leg aneurysm or dissection operationOP an Becken-/Beinarterien bei Aneurysma/Dissektion, MortalitätF.3.7.M28450.2481.7
Femoral neck fractureSchenkelhalsfraktur (Alter >19), MortalitätI.3.1.M853135.536234.2
Trochanteric fracturePertrochantäre Fraktur (Alter >19), MortalitätI.3.8.M740164.728873.9
Gastric, duodenal or jenjunal ulcer resection (no tumour)HD Ulcus von Magen, Duodenum oder Jejunum, ohne Tumor, Mortalitä"E.5.5.M398712.618504.6
Major pulmonary or bronchial resectionGrössere Resektionen von Lunge oder Bronchien insgesamt, MortalitätD.4.1.M325052.18782.7
TUR prostateProstata-TUR, MortalitätH.4.1.M1408539.02870.2
Hernia repair without intestinal operationHerniotomie ohne OP am Darm, MortalitätE.2.1.M34008321.83950.1
Hysterectomy (benign disease)Hysterektomie bei gutartigen Erkrankungen (Alter >14), MortalitätG.3.1.M16652210.7860.1
Extracranial vascular operationExtrakranielle Gefäss-OP, MortalitätF.1.1.M143240.9880.6
NephrectomyVollständige Nephrektomie, MortalitätH.1.1.M157781.02211.4
Amputation foot (no trauma)Amputation im Fussbereich, kein Trauma, MortalitätF.4.1.M254201.67102.8
Hernia repair with intestinal operationHerniotomie mit OP am Darm, MortalitätE.2.2.M45190.32545.6
Gastric carcinoma resectionMagenresektionen (ohne Ösophaguseingriff) bei Magenkarzinom, MortalitätE.5.2.M56590.42594.6
Nonruptured abdominal aortic aneurysm (open operation)Offene abdominale OP bei Aortenaneurysma nicht rupturiert, MortalitätF.2.2.M59610.42384.0
Arterial pelvic or leg thromboembolic operationOP an Becken-/Beinarterien bei arterieller Embolie/Thrombose, MortalitätF.3.5.M64370.43515.5
Colorectal resectionKolorektale Resektionen insgesamt, MortalitätE.4.1.M1474179.467714.6
Pancreatic resectionPankreasresektionen insgesamt (ohne Transplantation, Alter >19), MortalitätE.7.1.M100710.66226.2
Complex oesophageal procedureKomplexe Eingriffe am Ösophagus, MortalitätE.6.1.M44550.33107.0
Hip endoprosthesis (first implant, no fracture)Hüft-Endoprothese-Erstimplantation (nicht bei Frakturen), MortalitätI.1.1.M23894015.35030.2
CystectomyEntfernung der Harnblase (Zystektomie), MortalitätH.3.5.M64160.41983.1
Amputation lower limb (no trauma)Amputation untere Extremität, kein Trauma, MortalitätF.4.2.M99400.6110211.1
Total 22 indicators  1561012100.0221401.4

Summary descriptive statistics

The analysis of the selected 22 IORs included 1,561,012 operations (cases) and 22,140 in-hospital deaths, with an overall crude POMR of 1.42% over the study period 1998–2014. For 2014, all 22 IORs together represented 110,300 operations and 1506 deaths. Because a total of 63,938 people died in Switzerland in 2014, according to the Federal Statistical Office [55], the deaths reflected by these IORs represented 2.4% of the overall mortality in Switzerland in 2014. IOR groups were categorised according to the direction of POMR trends and to risk levels (mean age-adjusted POMR 1998–2014). The results of the direct age-adjustment and analysis of POMR time trends are presented in table 2 and table 3, and graphically visualised in figures 1–4. The HSM-relevant [18, 31] IORs pancreatic resection, oesophageal resection, and low resection of the rectum (part of the IOR group colorectal resections) fell into the IOR result group that had an unchanged time trend.

Table 2

Summary results of POMR trends.

Groups categorised by trend direction and riskRisk (mean age-adjusted POMR 1998–2014, (%))Cases% of casesDeaths% of deathsCrude POMR (%)
1. Decreasing POMR trends in low to intermediate risk IOR0.2–2.241821726.8974544.02.3
2. Unchanged POMR trends in low risk IOR0.1–0.970298045.017878.10.3
3. Unchanged POMR trends in intermediate risk IOR1.7–3.818451911.8880539.84.8
4. Increasing POMR trends in low to high risk IOR0.1–5.225529616.418038.10.7
Unchanged or increasing0.1–5.2114318673.21239556.01.1
All groups (1–4)0.1–5.21561012100.022140100.01.4

POMR = perioperative mortality rate; IOR = indicator operation

Table 3

Decreasing, unchanged, and increasing POMR time trends 1998–2014 for 22 indicator operations with various perioperative risk.

Indicator operation (IOR)CasesDeathsPOMR crude (%)POMR age-adj (%)AdjustmentIRR 1IRR 295% CIp-valueIRR 3.195% CIp-valueIRR 3.295% CIp-valueIRR F/M95% CIp-value
1. Decreasing POMR trends in low to intermediate risk IOR
Cholecystectomy (no tumour)183,6674590.20.2Crude11.180.95–1.480.1340.840.66–1.070.1590.7090.568–0.8850.002   
Age / Sex11.110.89–1.390.3370.750.58–0.950.0180.6690.536–0.8350.0000.580.48–0.690.000
Arterial pelvic or leg aneurysm or dissection operation2845481.70.6Crude10.840.43–1.620.5950.350.17–0.760.0070.4250.209–0.8630.018   
Age / Sex10.750.39–1.470.4090.340.16–0.720.0050.4450.219–0.9060.0260.990.44–2.250.987
Femoral neck fracture85,31336234.20.8Crude11.101.01–1.190.0241.010.93–1.100.8180.9200.851–0.9930.033   
Age / Sex11.050.97–1.140.2640.940.87–1.020.1590.9000.833–0.9720.0070.500.47–0.540.000
Trochanteric fracture74,01628873.90.9Crude11.010.92–1.110.8350.950.87–1.040.2660.9400.863–1.0250.159   
Age / Sex10.960.88–1.060.4470.880.80–0.960.0050.9100.835–0.9920.0320.420.39–0.460.000
Gastric, duodenal or jejunal ulcer resection (no tumour)39,87118504.61.7Crude11.040.93–1.160.4950.840.75–0.940.0030.8080.722–0.9040.000   
Age / Sex11.030.92–1.150.6190.780.69–0.870.0000.7550.674–0.8450.0000.910.83–1.000.048
Major pulmonary or bronchial resection32,5058782.72.2Crude10.880.74–1.040.1260.740.63–0.880.0000.8450.724–0.9860.032   
Age / Sex10.880.74–1.040.1360.730.62–0.860.0000.8300.711–0.9680.0180.590.51–0.690.000
2. Unchanged POMR trends in low risk IOR
TUR prostate140,8532870.20.1Crude10.970.74–1.290.8530.910.67–1.220.5170.9310.705–1.2310.617   
Age / Sex10.980.74–1.290.8710.890.66–1.200.4470.9120.690–1.2060.51911.082.74–44.790.001
Hernia repair without intestinal operation340,0833950.10.1Crude10.970.76–1.240.7990.970.76–1.240.8091.0010.792–1.2650.993   
Age / Sex10.930.73–1.190.5630.900.70–1.160.4080.9670.766–1.2220.7811.861.51–2.290.000
Hysterectomy (benign disease)166,522860.10.1Crude10.790.49–1.280.3420.580.33–1.020.0570.7350.415–1.3010.291   
Age / Sex10.740.46–1.200.2210.540.31–0.940.0300.7290.411–1.2930.2800.110.01–0.800.029
Extracranial vascular operation14,324880.60.6Crude10.900.54–1.470.6630.730.42–1.240.2440.8100.485–1.3540.422   
Age / Sex10.880.53–1.460.6250.670.39–1.160.1550.7610.455–1.2730.2991.060.68–1.660.791
Age / Sex10.910.66–1.250.5610.850.61–1.190.3540.9380.681–1.2930.6960.730.55–0.960.024
Amputation foot (no trauma)25,4207102.80.9Crude10.890.74–1.070.2141.000.83–1.200.9651.1210.943–1.3330.195   
Age / Sex10.850.70–1.020.0810.900.75–1.080.2601.0630.893–1.2640.4920.670.57–0.790.000
3. Unchanged POMR trends in intermediate risk IOR
Hernia repair with intestinal operation45192545.61.7Crude11.220.86–1.740.2661.180.83–1.660.3590.9620.733–1.2630.780   
Age / Sex11.190.84–1.700.3241.250.89–1.770.2021.0490.798–1.3770.7330.830.64–1.060.140
Gastric carcinoma resection56592594.61.8Crude11.140.86–1.510.3700.850.61–1.170.3100.7430.544–1.0150.062   
Age / Sex11.170.88–1.550.2830.860.62–1.190.3700.7390.541–1.0090.0570.600.46–0.780.000
Unruptured abdominal aortic aneurysm (open operation)59612384.01.9Crude10.870.63–1.190.3880.960.69–1.330.7851.0990.816–1.4810.536   
Age / Sex10.830.60–1.140.2450.900.65–1.260.5511.0930.810–1.4740.5601.230.88–1.720.232
Arterial pelvic or leg thromboembolic operation64373515.52.1Crude11.080.80–1.460.6261.090.81–1.450.5761.0070.797–1.2730.954   
Age / Sex11.100.81–1.490.5361.060.79–1.410.7150.9590.758–1.2130.7241.010.81–1.270.904
Colorectal resection147,41767714.62.2Crude11.131.06–1.200.0001.171.10–1.250.0001.0410.985–1.1000.154   
Age / Sex11.121.06–1.190.0001.151.08–1.230.0001.0270.972–1.0850.3360.750.72–0.790.000
Pancreatic resection10,0716226.23.4Crude11.090.89–1.350.4061.190.97–1.460.0991.0880.910–1.3010.352   
Age / Sex11.020.83–1.270.8231.080.87–1.320.4901.0500.878–1.2560.5910.740.63–0.870.000
Complex oesophageal procedure44553107.03.8Crude11.050.80–1.370.7470.880.67–1.160.3670.8410.642–1.1020.209   
Age / Sex10.970.74–1.270.8250.800.60–1.060.1200.8260.630–1.0820.1650.990.77–1.280.941
4. Increasing POMR trends in low to high risk IOR
Hip endoprosthesis (first implant, no fracture)238,9405030.20.1Crude10.580.46–0.720.0000.760.62–0.940.0101.3171.061–1.6350.013   
Age / Sex10.570.46–0.720.0000.720.59–0.890.0021.2611.016–1.5660.0360.730.61–0.870.000
Age / Sex10.930.62–1.390.7141.581.09–2.290.0171.7011.231–2.3520.0010.980.72–1.350.924
Amputation lower limb (no trauma)9940110211.15.2Crude11.010.88–1.170.8511.241.07–1.440.0041.2231.056–1.4170.007   
Age / Sex11.050.91–1.210.5171.281.10–1.480.0011.2181.051–1.4100.0090.910.80–1.030.146

POMR = perioperative mortality rate; IOR = indicator operation; age-adj = age-adjusted; IRR = incident-rate ratio; IRR 1 = reference for comparing three consecutive time intervals and is therefore 1 for first period; IRR 2 = IRR for comparison time intervals 2/1; IRR 3.1 = IRR for comparing time intervals 3/1; IRR 3.2 = IRR for comparing time intervals 3/2; 95% CI = 95% confidence interval; IRR F/M = IRR for testing impact of female (versus male) sex on POMR; p = two-tailed p-value.

Figure 1
Decreasing POMR trends in low- to intermediate-risk IORs.
Note: POMR = perioperative mortality rate.
Figure 2
Unchanged POMR trends in low-risk IORs.
Note: POMR = perioperative mortality rate. Sex-specific analyses were not completed for sex-specific operations (hysterectomy, TUR prostate; see methods section). Note that different percentage scales are used for the upper three and the lower three IORs.
Figure 3
Unchanged POMR trends in intermediate-risk IORs.
Note: POMR = perioperative mortality rate.
Figure 4
Increasing POMR trends in low- to high-risk IORs.
Note: POMR = perioperative mortality rate. Note also that different percentage scales are used for the first IOR and the second and third IOR.

Impact of sex on POMR

Sex-specific IORs (hysterectomy, TUR prostate) included 307,375 operations (19.7% of all operations). Of the remaining 20 IORs, including 1,253,637 operations (80.3% of all operations), 11 IORs including 858,657 operations (68.5% of remaining operations) had significantly lower POMRs in females; 8 IORs including 54,897 operations (4.4% of remaining operations) had no sex difference. POMRs were significantly higher for females in the IOR of hernia repair without intestinal operation which included 340,083 operations (27.1% of remaining operations; IRR 1.86, 95% CI 1.51–2.29).


We present the time trends of age-standardised perioperative in-hospital mortality rates (POMRs) for selected noncardiac surgical indicator operations (IORs) published by the Swiss FOPH for the years 1998–2014 for 22 noncardiac surgical IORs, representing 1,561,012 individual operations and 22,140 in-hospital deaths, and corresponding to an overall crude POMR of 1.42%. We found that the long-term POMR time trends are not generally decreasing in Switzerland. In contrast, for a substantial number of IORs the POMRs did not change, and a few POMRs even increased. Female sex was associated with a lower POMR in most IORs. The methods used represent a way of calculating and presenting POMR trends that could be adopted for routine use.

The strengths of our study are the completeness of the national data sets for IORs, the availability of data for all years of the study period for selected IORs, and the better comparability of yearly populations after direct age standardisation. However, a number of limitations need to be considered [56]. First, operations, not patients, represent the individual observations in the publicly available FOPH data, and hence the denominator for the POMR. Because one patient could have represented several cases in some IORs, a case-based POMR may theoretically underestimate a patient-based POMR. Second, the results may be affected by bias – selection bias may have been introduced by selecting IORs according to the inclusion and exclusion criteria. In particular, IORs for which reporting began after 1998 were not included. Within the individual IOR data, bias may have been introduced during the reporting process. Third, IOR data may have been significantly influenced by varying coding practices in hospitals, for example after the introduction of diagnosis-related group (DRG)-based quality reporting and reimbursement in Switzerland on January 1, 2012 (SwissDRG) [57]. Indeed, several international studies have documented faulty, missing or incorrect coding of diagnoses and procedures after introduction of DRG [5860], restructuring of procedure codes [61], and changes in comorbidity coding [62]. After the introduction of SwissDRG in 2012, readmission within 18 days leads to coding of the readmission as one hospital stay or case together with the initial hospitalisation [63]. Whereas DRG-related comorbidity coding is unlikely to have impacted our results significantly (comorbidity data were not part of the analysed data sets), the changed readmission coding might have influenced our results: If a patient died in hospital after readmission, this may have escaped coding as POM before introduction of SwissDRG, but should have been captured afterwards. This coding rule may have led to higher in-hospital POMRs in the last of the three time intervals we defined. However, this potential impact is not related to the type of IOR and might affect all POMR trends, not only increasing POMR trends. Notably, a recent study reported no relationship between SwissDRG introduction and intensive care unit mortality in Switzerland [64]. The data sets analysed in our analysis, however, did not allow us to further investigate these issues. Fourth, the data and results may have been affected by changes in the organisation and delivery of healthcare. In Switzerland, the mandatory reporting of quality indicators is limited to inpatients. A recent project to extend such reporting to the ambulatory setting has not yet been fully implemented [65, 66], and procedures may have been shifted from the inpatient to the ambulatory setting in Switzerland during the study period, in line with international trends (e.g., TUR prostate [67], hysterectomy [68], hip arthroplasty [69], colectomy [70], cholecystectomy [71]). Furthermore, in-hospital mortality (used for FOPH IOR [13]) may overestimate [72] or underestimate [73] 30-day mortality [72, 74]. Postoperative patient transfers to secondary institutions may have affected the data and reporting [75]. Fifth, owing to the limitations of the FOPH data used in this analysis, we could not assess if trends differed for emergency interventions compared to non-emergency interventions.

The results of this analysis should be interpreted cautiously in light of the study objectives and limitations, and pre-existing evidence [75].The study objective was to analyse POMR time trends for selected IORs at the national level from a public health perspective on monitoring the overall performance of the healthcare system [1]. A comprehensive exploration of the specific conditions and causes of individual IOR trends is beyond the objectives of this study and of the presented monitoring approach, and should be addressed by more detailed investigations [7]. Indeed, the POMR has limited value at the level of individual hospitals, where the case mix may vary [76], but is increasingly used as a quality indicator for monitoring the overall performance of surgical healthcare at the regional or national level [1, 3, 4, 8] and has been recommended by the WHO [5] and the Lancet Commission on Global Surgery [6, 7] as a core healthcare indicator.

What could be the utility of using POMR trends as a surveillance instrument for monitoring the overall performance of surgical care at the national level? Some of our results deviate from evidence that has been reported in the international literature, highlighting the importance of individually monitoring the performance of healthcare systems, because organisational, population-based and other factors may differ between countries. In contrast to our findings, decreasing POMR trends for high-risk procedures have been reported in the US, which may be related to the inclusion of different IORs or to other factors [77]. For cystectomy, in-hospital mortality was unchanged from 2001–2008 in the US [78], and 30-day and 90-day mortality decreased between 1998 and 2010 in England [79]. According to an Australian single-centre study, the 30-day, 6-month and 1-year mortality after major lower limb amputation decreased dramatically between 2000–2002 and 2010–2012, which was attributed, in part, to organisational changes [80]. A study from the US then reported declining in-hospital mortality from 1998–2008 after total hip arthroplasties despite increasing trends in in-hospital major complications, but because the length of hospital stay also decreased significantly during the same period, the authors point out that some of the postoperative deaths may have occurred after the transfer of the patients to other facilities [75]. In addition to these international findings, lower hospital volume was associated with higher mortality after oesophageal, gastric, pancreatic and rectal cancer resections in a Swiss study (1999–2012) [81]. This study also documented an increasing concentration of these procedures in centres with higher volumes, but the overall POMR trends for these procedures are not evident from this study [81].

The external validity [56] of our findings is crucial for their potential transfer to practice. The results for individual IORs are based on mandatory data collection for all Swiss hospitals and represent a national census rather than a sample for the respective indicator. Importantly, routine quality reporting of surgical outcomes has been found to have a beneficial effect on quality outcomes per se [82, 83], and to be effective for measuring the impact of quality improvement strategies on mortality [84]. Allowing for the limitations of the routine data collection processes and the specific indicator definitions, POMR trends for individual FOPH IORs appear to be valid for use as indicators for perioperative care at the national level in Switzerland. The presented approach of calculating and presenting POMR trends based on direct standardisation and trend analysis using Poisson regression is methodically straightforward and could be done regularly to complement the reports of the FOPH.


For 73% of the included cases of selected noncardiac surgical indicator operations, in-hospital POMR trends in Switzerland were unchanged or increasing from 1998–2014. Potential confounding factors include changes in the coding practices and in the organisation of healthcare delivery. Unexpected POMR trends should be further investigated to identify potentially preventable factors amenable to national quality improvement strategies or to detect practice variations related to the reporting and coding process. The presented methodology may be used to monitor POMRs at the national level in Switzerland.


The authors would like to acknowledge the valuable contributions of the following individuals and institutions: Theres Schneider, Manfred Langenegger, FOPH; Matthias Fügi, GDK; Paul op’t Roodt, Hirslanden Clinic; David Schwappach, Patientensicherheit Schweiz; Kristen Jafflin, University of Basel; Claudine Burton-Jeangros, University of Geneva; Beate Sick, University of Zurich; Sebastian Heinz, Statworx; American Journal Experts (www.aje.com; editing and formatting).

Financial disclosure

Funding was entirely provided by the authors and their institutions.

Potential competing interests

The authors have no competing interest regarding the study contents.


Header image: © Jesada Wongsa | Dreamstime.com


Dr Johannes Wacker, MD, Hirslanden Clinic, Witellikerstrasse 40, CH-8032 Zurich, Jwac[at]gmx.net


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Appendix 1

Technical appendix

Legal background, data collection, processing, and controlling processes

Swiss hospitals collect data yearly according to variables defined by the medical statistics of hospitals [22]. Hospitals can check data plausibility using software provided by the Federal Statistical Office [13]. Mortality always defines a case as an “inpatient” hospital stay [22]. Hospitals send the data to the Cantonal Statistical Offices, which organise and supervise data collection, check data quality, validate the data sets, and transfer them to the Federal Statistical Office. The Federal Statistical Office, responsible for the data collection at the federal level, publishes the medical statistics of hospitals [22] and transfers the necessary data required to establish the CH-IQIs to the FOPH [13].

Data import and file preparation – Data import, clearance, preparation of files and variables

To reconstruct all omitted age group observations, including sex-specific layers, a full set of age group observations for one year was first inserted as a “dummy” year at the end of the data list after sorting the “year” variable. The “dummy” observations contained 2050 as a “year” value to avoid confusion with real values in the data set, as well as a complete range of age groups (1–20) with two sex-specific layers (1=male, 2=female), resulting in 40 observations for “2050”. The observations of “year=2050” generated corresponding complete values (1–40) for “agegr” and “sex”, which were used temporarily as templates for all possible interactions between “year” and “agegr”, allowing the Stata command “fillin” [34] to generate a rectangular data structure and fill in omitted observations and their values as “missing”. The “fillin”-generated missing values were then replaced by zeros, and the 40 “dummy observations” were deleted.

Direct standardisation using the 2013 European Standard Population

As a standard population, the 2013 European Standard Population (ESP) was used (including the recommendation not to disaggregate the standard population by sex [19]). The FOPH publishes age-group-specific data for the following 20 5-year strata: age group 1 = 0–4 yrs, 2 = 5–9 yrs; 3 = 10–14 yrs; 4 = 15–19 yrs; 5 = 20–24 yrs, etc., until 18 = 85–89 yrs; 19 = 90–94 yrs; and 20 = 95+ yrs. These age groups deviate minimally from the ESP, where the youngest group is divided into two groups 0–<1 and 1–4 [19]. For this project (adults), the ESP-based standard population was adapted to the FOPH groups, combining the first two into one group (1–4 years), with a strata-specific combined population of 1000+4000=5000 [19]. A Stata file was created accordingly, containing variables with the adapted age group and population size variables.

Direct standardisation

Directly standardised POMRs were calculated using the Stata command “distrate” [36, 37]. The “distrate” command calculates the standardised rates and 95% confidence intervals (95% CIs) for standardised rates and is used, for example, in cancer registries [37]. “distrate” offers several options for calculating 95% CIs that are based on different assumptions about the underlying data distribution [37]. We used the method proposed by Dobson et al. [38] based on the χ2 distribution for the calculation of 95% CIs.

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