a Emergency Department, University Hospital Basel, Switzerland
b Medical Communication and Psychosomatic Medicine, University Hospital Basel, Switzerland
With the progress in healthcare over recent decades and a growing life expectancy, discussions and decisions regarding end-of-life issues have become increasingly important. Especially in intensive care and emergency medicine there is a growing need of decision making for optimised end-of-life care. Prolonging life and preventing death is considered to be the highest principle of healthcare professionals; however, in some cases alleviation of suffering is a more appropriate goal. This article discusses communication challenges in end-of-life decision making and outlines strategies from an area of growing interest and research.
Keywords: end-of-life, medical futility, advance care planning, breaking bad news
With the progress in healthcare over recent decades and a growing life expectancy, discussions and decisions regarding end-of-life (EOL) issues have become increasingly important. Especially in intensive care and emergency medicine there is a growing need of decision making for optimised EOL care .
Prolonging life and preventing death is considered to be the highest principle of healthcare professionals, however, in some cases alleviation of suffering is a more appropriate goal.
This article discusses communication challenges in EOL decision making and outlines strategies from an area of growing interest and research.
Discussion of end-of-life aspects with patients – with good communication skills
To assess patients’ goals of care and establish a corresponding treatment, discussions with patients or their caregivers are essential. Still, in many patients with palliative diseases (e.g., metastatic cancer or neurodegenerative disorders), in which the relief of suffering is the primary goal of care, EOL discussions do not occur [2, 3]. The reasons for this are manifold. First, communication in the EOL setting is often perceived as a challenge as physicians frequently have to talk about conditions for which prognoses or outcome are uncertain . Difficulties may arise if patients’ understanding of the disease is unrealistic or confidence in treatment is too optimistic [5, 6].
Another barrier which hampers EOL discussions is the physician’s concern about a negative impact on patients’ or caregivers’ emotional well-being, such as giving up hope . However, studies have shown that addressing patients’ preferences and goals of care in EOL discussions are associated with greater satisfaction with communication and decision making . Also, talking about prognosis and death is not necessarily perceived as stressful [2, 8]. A lack of communication skills constitutes a barrier for EOL conversations, with many physicians feeling unprepared or inexperienced [9, 10]. Communication training for physicians is often inadequate or simply not available [11, 12].
Especially in intensive care unit (ICU) or emergency settings, EOL discussions are often in conflict with busy daily routine and time constraints, impeding the chance to discuss patients’ values and needs [13–16]. A recent study from Basel found that treating physicians significantly altered patient choices regarding their preferred care in the case of a cardiac arrest, raising the question of patient autonomy .
Breaking bad news (BBN) to a patient or patient’s relatives represents an important but challenging task for physicians. It may change a patient’s life and view of their future, as bad news in EOL situations is most often the disclosure of incurable diseases, palliative treatment or the fact that patients may not return to their life at home but require advanced care.
To convey the bad news, healthcare professionals should make arrangements such as choosing an appropriate room or the avoidance of interruptions. Research has shown that patients prefer to receive bad news in person with enough time for questions . The request for the optimal amount of information however may vary by age, health literacy or among different cultures. Hence, it is important for BBN discussions to ascertain patients’ individual preferences. Proficient delivery with the help of specific communication strategies such as BAD can reduce patients’ or relatives’ burden. BAD is an acronym, standing for “Break bad news”, “Acknowledge the reaction” and “Discuss the near future”. Developed in the area of oncology research alongside SPIKES (Setting up the interview, Assessing the patient’s perception, Obtaining the patient’s invitation, Giving knowledge and information to the patient, Addressing the patient’s emotions with empathic responses, Strategy and summary) , BAD is regarded as one of the most established communication strategies for BBN today. Table 1 illustrates the different steps of the BAD strategy.
|Break bad news|
|Do I have all the necessary information? (e.g., medical results, circumstances in which the patient was brought to hospital)|
|What kind of information does the patient already have (e.g., already informed about diagnoses? Does the patient know the purpose of the conversation?)|
|Announcement of bad news with a “warning shot” (e.g., "I am afraid, I do not have good news for you…” or “I am sorry, but I have to inform you…”)|
|KISS – “Keep it short and simple”, concise wording of news (e.g., “we have found malignant cells in your biopsy, which means that you have cancer”; “your father has died”)|
|Acknowledge the reaction|
|Wait (at least three seconds; maintain eye contact)|
|Address patient’s emotions (NURSE, see below)|
|Avoid premature reassurance (e.g., “everything is going to be okay”)|
|Respond to patient’s questions|
|Discuss the near future|
|Give information that the patient requires now|
|What are the concrete next steps?|
|Amend bad news with good news (if possible)|
|Make follow-up appointment|
|Naming (e.g., “this must come as a shock…”, “I have the impression that…”)|
|Understanding (e.g., "this is absolutely understandable…", "I have no idea, how sad this must be for you")|
|Respecting (e.g., “I admire that you are so active despite your illness”)|
|Supporting (e.g., “Do you need any information/help?”, "here is my phone number, in case you have further questions”)|
|Exploring (e.g., “I wonder what you are thinking about...”, “would you like to tell me what you are thinking about…?”)|
The BAD strategy, as well as SPIKES, focusses on patients’ emotions evoked by the bad news. To address these emotions, physicians may use patient-centred communication techniques summarised in the acronym NURSE (naming, understanding, respecting, supporting and exploring). During BBN, naming and/or mirroring patients’ emotions as well as understanding statements are especially helpful tools to show compassion towards the patient (table 1). Research has shown that in BBN conversations emotional opportunities are often missed . However, addressing emotions may improve patients’ or relatives’ long-term adjustment to the bad news and its consequences.
Although sometimes done with good intentions, physicians should avoid premature reassurances (e.g., “It is not that bad…”, “Everything is going to be fine”) [21, 22]. First, if patients’ emotions are not addressed adequately, premature reassurance may be perceived by patients as not respecting their worries and fears. Also, the prognosis of a patient’s disease is sometimes difficult to predict and, thus, “premature reassurance” can be perceived as misleading information in the event of deterioration.
At the end of a BBN conversation, physicians should inform the patient or relative about the next steps. Often, it is advisable to make a follow-up appointment to discuss more detailed treatment plans, as patients’ capacity to absorb information is limited after the disclosure of bad news.
Over past decades, the use of intensive care at the end of life has increased steadily. Especially in the case of EOL decisions, such as withdrawal of therapy, relatives experience a high amount of psychological stress, which can affect their well-being. Studies report that up to two third of relatives of patients dying in the ICU show psychological sequelae such as depression, anxiety, complicated grief or post-traumatic stress disorder [23–27].
A study by Lautrette et al. has shown that proactive communication can reduce the risk of developing depression or symptoms of a post-traumatic stress disorder in relatives of ICU patients . The study used a structured communication strategy summarised by the mnemonic VALUE (table 2). This strategy recommends to value and appreciate statements of family members, acknowledge their emotions, as well as to listen and ask questions to understand who the patient was as a person. These steps help the physician to adopt an empathic attitude and to build rapport with the family members during an EOL discussion. Eliciting questions enables physicians to engage family members in the discussion, help them to voice concerns and clear up misconceptions.
|Value and appreciate family statements|
|Acknowledge family emotions|
|Listen to the family and ask questions|
|Understand patient as a person|
|Elicit family questions|
The VALUE communication strategy led to EOL conversations in which caregivers had more opportunities to voice concerns and emotions. Also, caregivers were more likely to agree to realistic goals of care, experienced less decisional conflict and, most importantly, experienced less psychological burden.
In conclusion, with a growing need of EOL care, communication with dying patients or their relatives will become increasingly important as a core competence for all caregivers. Today, most people die in hospitals even though the majority of patients would prefer to spend their final days at home . This highlights the need for training in communication skills in EOL settings to help explore and respect patients’ preferences in these crucial situations and to make medically meaningful but also patient-centred decisions.
Advance care planning
Patient autonomy and participation in EOL decision-making are valued as high quality of care . Therefore, the awareness of patients’ preferences regarding future medical treatments should be a central element of care for patients, especially in patients with advanced illness. A timely initiation of advance care planning (ACP) gives patients the opportunity to receive their preferred care early on . General practitioners are often in the unique position of having a long-term relationship with their patients and relatives, which constitute a good basis for the early start of ACP . Still, the occurrence of ACP in the general practice setting remains low [35, 36].
If a patient’s preference is unknown or a patient is not able to express his or her treatment preference, the patient’s next of kin often act as surrogate decision-makers, potentially increasing their emotional burden.
Advanced directives (AD), as a set of instructions, may convey a patient’s wishes to family members and/or healthcare professionals . ADs may also designate a patient’s next of kin as surrogate decision-makers in case the patient is incapacitated. Recent surveys showed that about 28% of the Swiss population above 55 years of age had completed an AD [3, 38]. However, many advanced directives only focus on specific intensive care treatments such as cardiopulmonary resuscitation or intubation, and do not properly address other components of care. Also, ADs often do not provide enough clarity about the goals of care, limiting their usability in clinical settings [39, 40]. ACP was originally developed to overcome such shortcomings by allowing patients to state preferences of care and to document potential treatment plans pre-emptively [33, 41].
Literature has shown that ACP not only improves care towards the end of life, but also reduces stress and depression in surviving relatives and helps physicians make end-of-life decisions in accordance with patients’ preferences . Over past years, different treatment plans have emerged, such as Physician Orders for Scope of Treatment (POLST), Medical Orders for Scope of Treatment (MOLST) or Recommended Summary Plan for Emergency Care and Treatment (ReSPECT), which combine discussions about resuscitation with other goals of emergency care [42, 43].
To facilitate such ACP discussions, physicians may use decision aids. Decision aids are tools that illustrate medical information and provide a better understanding for lay people. Patients with a low health literacy and difficulties in processing medical information especially benefit from these interventions, enabling them to participate in the decision-making regarding their own care. Recent research has shown that decision aids increase patient knowledge and reduce patients’ decisional conflicts, as patients show higher clarity about which goals of care are the most important to them [44, 45]. For example, videos explaining the nature and outcome of cardiac arrests have been used to increase patient knowledge and were associated with patients preferences towards less invasive treatments in the event of clinical deterioration . A variety of other examples of decision aids are listed in the decision aid inventory of the Ottawa Hospital Research Institute. Table 3 presents a selection of decision aids targeting end-of-life decisions.
|Title||Author/developer||Year||Health condition / topic||Type||Content||Language||Link|
|A Decision Aid to Prepare Patients and Their Families For Shared Decision-Making About Cardio-Pulmonary Resuscitation (CPR)||Jennifer Kryworuchko||2012||Cardiopulmonary resuscitation||Video||Video explaining cardiac arrest and cardiopulmonary resuscitation and its prognosis||English||https://vimeo.com|
|Cardiopulmonary resuscitation: a decision aid for patients and their families||Chris Frank||2009||Cardiopulmonary resuscitation||Written material||Giving information about Cardiopulmonary resuscitation / life support and its outcome|
giving information regarding advanced directives
|Advance Care Planning: Should I Receive CPR |
and Life Support?
End of life issues
|Written material||Giving information about cardiopulmonary resuscitation / life support and its outcome|
giving information regarding DNR orders
|Autopsy: Should I have an autopsy done on my loved one?||Healthwise||2016||Autopsy of next of kin after death||Written material||Giving information about autopsy (indications and considerations)||English||https://decisionaid.ohri.ca|
|Understanding the Options: Planning care for critically ill patients in the Intensive Care Unit.||Jennifer Kryworuchko||2015||Life prolonging / palliative care||Written material||Information/considerations about life prolonging / palliative care; scaling questions to determine patient's preferences and goals of care||English||https://decisionaid.ohri.ca|
|Advance Care Planning: Should I stop treatment that prolongs my life?||Healthwise||2016||Life prolonging / palliative care||Written material||Giving information about life prolonging and palliative care, considerations||English||https://decisionaid.ohri.ca|
|Advance Care Planning: Should I have artificial |
hydration and nutrition
|Healthwise||2016||Artificial Hydration and Nutrition||Written material||Giving information regarding hydration/ nutrition|
explaining advantages and disadvantages of artificial hydration/nutrition
|Advance Care Planning: Should I stop kidney dialysis?||Healthwise||2016||Chronic kidney failure / Dialysis||Written material||Giving information about dialysis, explaining advantages/disadvantages of stopping dialysis||English||https://decisionaid.ohri.ca|
|Kidney Failure: Should I Start Dialysis?||Healthwise||2016||Chronic kidney failure / dialysis||Written material||Giving information about chronic kidney failure and dialysis||English||https://decisionaid.ohri.ca|
|Breathing with a Ventilator: Stop or Stay On?||EBSCO Health||2019||Patients dependent on a ventilator||Written material||Information about staying or removing from a ventilator (advantages and risks)||English||https://decisionaid.ohri.ca|
|When you need extra care, should you receive it at home or in a facility?||Mary Ann Murray||2010||Patients dependent on care||Written material||Information about care at home vs. in a facility; scaling questions to determine patient's preferences||English||https://decisionaid.ohri.ca|
|Prepare for your care||The Regents of the University of California||2020||Advance directive||Website||Interactive website offering information regarding end-of-life decision making||English|
|Entscheidungshilfe Herz-Lungen-Wiederbelebung||Advance care planning medizinisch begleitet ®||2017||Cardiopulmonary resuscitation||Written material||Information about cardiac arrest / cardiopulmonary resuscitation; Cates plot illustrating risk of death / hypoxic encephalopathy||German||https://www.pallnetz.ch|
|DNR = do-not-resuscitate|
As a result of a considerable increase in medical interventions available to patients over past decades, physicians regularly encounter situations in which a treatment is considered medically futile for a specific patient. A recent study on patients in the ICU found that more than 10% of patients received treatment perceived as futile by their treating clinicians . In the context of EOL care, medical futility often refers to interventions that might prolong life, but in which the chance of a benefit for the patient is extremely small and by far outweighed by the potential risks, harms and suffering [47–49]. Such situations are challenging for clinicians and the clinical team, who know the potential burden and distress resulting from a futile intervention for patients and relatives [50, 51]. Several factors contribute to the difficulty in decision making in such situations. First, although physicians may agree to the overall concept of medical futility, this concept is difficult to apply in clinical practice, as the clinical course of the illness and the outcome of interventions are sometimes difficult to foresee [52–54]. This is particularly true for EOL care. Second, judgment of futility is often based on a clinical impression . This incorporates objective medical data from the patient history and subjective data from patient’s currently perceived and future expected quality of life, as well as potential benefits and harm associated with the treatment [55–57]. Interpretation of these different variables may contribute to the ambiguity regarding futility for an individual patient [53, 54]. Disclosing that a specific treatment is considered futile and that EOL should be adapted accordingly can be challenging . Even though patients and physicians may agree on the overall treatment goals, an overestimation of the chance of positive outcomes due to misconceptions and lack of knowledge on the patients’ side contributes to difficulties in reaching consensus on a specific treatment.
Cardiopulmonary resuscitation (CPR) for in-hospital cardiac arrests is one of the treatments in which medical futility is important to consider . CPR was originally developed to resuscitate healthy patients who suffered from a sudden cardiac arrest. Nowadays, however, CPR is commonly offered to all patients as an intervention, regardless of the underlying reason for the cardiac arrest. Prognosis of in-hospital cardiac arrest (IHCA) is poor, with a survival rate of less than 20% . Further, many ÌHCA survivors are dependent on long-term care or suffer from permanent brain injury after CPR . For about two decades, the Pre-arrest Morbidity (PAM) index  and Prognosis after Resuscitation (PAR) score  were the most commonly used clinical risk scores to evaluate prognosis after CPR for IHCA. Although these scores did show sufficient validity in several studies [58, 61, 63], optimal cut-off values differed depending on clinical and sociodemographic characteristics of the respective patient population . Recently, the Good Outcome Following Attempted Resuscitation (GO-FAR) score has been developed and validated in large samples of patients [65–69]. Also, a modified version has been proposed: The Prediction of Outcome for In-Hospital Cardiac Arrest (PIHCA) score . These scores incorporate clinical conditions that are associated with poor outcome such as metastatic cancer, advanced renal failure or sepsis. The authors developed a multivariate prediction model based on a meta-analysis including patients who suffered from an in-hospital cardiac arrest and calculated cut-off scores suggesting the chance of neurologically intact survival, such as “very low” (0.9% of patients have a good neurological outcome), “low” (1.7%), “average” (9.4%) and “above average” (27.5%) (the GO-FAR score can be accessed under https://www.gofarcalc.com/). For patients with a very low and low chance of functional survival CPR attempts may be considered futile .
Both scores show promising predictive values regarding implementation in clinical practice.
Especially in cases of uncertainty, these clinical risk scores may be a useful additional tool for physicians to assess medical futility, foster decision making in EOL, and to facilitate conversations with patients and their next of kin. This could further support patients and their next of kin in making informed EOL decisions aligned with their personal values and treatment goals.
With an aging society, decision making and adequate communication in EOL decisions are becoming increasingly important. Incorporating individuals’ needs and preferences is crucial. Although there are potential barriers to conducting EOL discussions, it is worth taking the time and effort to optimise EOL conversations. Proactive communication can not only ease patients’ and relatives’ psychological burden but can also prevent them from developing long-term mental health issues.
No financial support and no other potential conflict of interest relevant to this article was reported.
Header image: © Navee Sangvitoon | Dreamstime.com
Christoph Becker, MD, Emergency Department and Medical Communication and Psychosomatic Medicine, University Hospital Basel, Petersgraben 4, CH-4031 Basel, christoph.becker[at]usb.ch
1 Etkind SN, Bone AE, Gomes B, Lovell N, Evans CJ, Higginson IJ, et al.How many people will need palliative care in 2040? Past trends, future projections and implications for services. BMC Med. 2017;15(1):102. doi:. http://dx.doi.org/10.1186/s12916-017-0860-2 PubMed
2 You JJ, Dodek P, Lamontagne F, Downar J, Sinuff T, Jiang X, et al.; ACCEPT Study Team and the Canadian Researchers at the End of Life Network (CARENET). What really matters in end-of-life discussions? Perspectives of patients in hospital with serious illness and their families. CMAJ. 2014;186(18):E679–87. doi:. http://dx.doi.org/10.1503/cmaj.140673 PubMed
3 Becker C, Künzli N, Perrig S, Beck K, Vincent A, Widmer M, et al.Code status discussions in medical inpatients: results of a survey of patients and physicians. Swiss Med Wkly. 2020;150:w20194. PubMed
4 Krawczyk M, Gallagher R. Communicating prognostic uncertainty in potential end-of-life contexts: experiences of family members. BMC Palliat Care. 2016;15(1):59. doi:. http://dx.doi.org/10.1186/s12904-016-0133-4 PubMed
5 Jones GK, Brewer KL, Garrison HG. Public expectations of survival following cardiopulmonary resuscitation. Acad Emerg Med. 2000;7(1):48–53. doi:. http://dx.doi.org/10.1111/j.1553-2712.2000.tb01891.x PubMed
6 Weeks JC, Cook EF, O’Day SJ, Peterson LM, Wenger N, Reding D, et al.Relationship between cancer patients’ predictions of prognosis and their treatment preferences. JAMA. 1998;279(21):1709–14. doi:. http://dx.doi.org/10.1001/jama.279.21.1709 PubMed
7 Hancock K, Clayton JM, Parker SM, Wal der S, Butow PN, Carrick S, et al.Truth-telling in discussing prognosis in advanced life-limiting illnesses: a systematic review. Palliat Med. 2007;21(6):507–17. doi:. http://dx.doi.org/10.1177/0269216307080823 PubMed
8 Emanuel EJ, Fairclough DL, Wolfe P, Emanuel LL. Talking with terminally ill patients and their caregivers about death, dying, and bereavement: is it stressful? Is it helpful?Arch Intern Med. 2004;164(18):1999–2004. doi:. http://dx.doi.org/10.1001/archinte.164.18.1999 PubMed
9 Covinsky KE, Fuller JD, Yaffe K, Johnston CB, Hamel MB, Lynn J, et al.; The Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments. Communication and decision-making in seriously ill patients: findings of the SUPPORT project. J Am Geriatr Soc. 2000;48(S1, Suppl):S187–93. doi:. http://dx.doi.org/10.1111/j.1532-5415.2000.tb03131.x PubMed
10 Tulsky JA, Fischer GS, Rose MR, Arnold RM. Opening the black box: how do physicians communicate about advance directives?Ann Intern Med. 1998;129(6):441–9. doi:. http://dx.doi.org/10.7326/0003-4819-129-6-199809150-00003 PubMed
11 Walczak A, Butow PN, Bu S, Clayton JM. A systematic review of evidence for end-of-life communication interventions: Who do they target, how are they structured and do they work?Patient Educ Couns. 2016;99(1):3–16. Published online September 26, 2015. doi:. http://dx.doi.org/10.1016/j.pec.2015.08.017 PubMed
12 Cegala DJ, Lenzmeier Broz S. Physician communication skills training: a review of theoretical backgrounds, objectives and skills. Med Educ. 2002;36(11):1004–16. doi:. http://dx.doi.org/10.1046/j.1365-2923.2002.01331.x PubMed
13 Visser M, Deliens L, Houttekier D. Physician-related barriers to communication and patient- and family-centred decision-making towards the end of life in intensive care: a systematic review. Crit Care. 2014;18(6):604. doi:. http://dx.doi.org/10.1186/s13054-014-0604-z PubMed
14 Knauft E, Nielsen EL, Engelberg RA, Patrick DL, Curtis JR. Barriers and facilitators to end-of-life care communication for patients with COPD. Chest. 2005;127(6):2188–96. doi:. http://dx.doi.org/10.1378/chest.127.6.2188 PubMed
15 Momen NC, Barclay SI. Addressing ‘the elephant on the table’: barriers to end of life care conversations in heart failure - a literature review and narrative synthesis. Curr Opin Support Palliat Care. 2011;5(4):312–6. doi:. http://dx.doi.org/10.1097/SPC.0b013e32834b8c4d PubMed
16 Deep KS, Griffith CH, Wilson JF. Communication and decision making about life-sustaining treatment: examining the experiences of resident physicians and seriously-ill hospitalized patients. J Gen Intern Med. 2008;23(11):1877–82. doi:. http://dx.doi.org/10.1007/s11606-008-0779-6 PubMed
17 Siegrist V, Eken C, Nickel CH, Mata R, Hertwig R, Bingisser R. End-of-life decisions in emergency patients: prevalence, outcome and physician effect. QJM. 2018;111(8):549–54. doi:. http://dx.doi.org/10.1093/qjmed/hcy112 PubMed
18 Figg WD, Smith EK, Price DK, English BC, Thurman PW, Steinberg SM, et al.Disclosing a diagnosis of cancer: where and how does it occur?J Clin Oncol. 2010;28(22):3630–5. doi:. http://dx.doi.org/10.1200/JCO.2009.24.6389 PubMed
19 Baile WF, Buckman R, Lenzi R, Glober G, Beale EA, Kudelka AP. SPIKES-A six-step protocol for delivering bad news: application to the patient with cancer. Oncologist. 2000;5(4):302–11. doi:. http://dx.doi.org/10.1634/theoncologist.5-4-302 PubMed
20 Pollak KI, Arnold RM, Jeffreys AS, Alexander SC, Olsen MK, Abernethy AP, et al.Oncologist communication about emotion during visits with patients with advanced cancer. J Clin Oncol. 2007;25(36):5748–52. doi:. http://dx.doi.org/10.1200/JCO.2007.12.4180 PubMed
21 Razavi D, Merckaert I, Marchal S, Libert Y, Conradt S, Boniver J, et al.How to optimize physicians’ communication skills in cancer care: results of a randomized study assessing the usefulness of posttraining consolidation workshops. J Clin Oncol. 2003;21(16):3141–9. doi:. http://dx.doi.org/10.1200/JCO.2003.08.031 PubMed
22 Giroldi E, Veldhuijzen W, Leijten C, Welter D, van der Weijden T, Muris J, et al.‘No need to worry’: an exploration of general practitioners’ reassuring strategies. BMC Fam Pract. 2014;15(1):133. doi:. http://dx.doi.org/10.1186/1471-2296-15-133 PubMed
23 Metzger K, Gamp M, Tondorf T, Hochstrasser S, Becker C, Luescher T, et al.Depression and anxiety in relatives of out-of-hospital cardiac arrest patients: Results of a prospective observational study. J Crit Care. 2019;51:57–63. doi:. http://dx.doi.org/10.1016/j.jcrc.2019.01.026 PubMed
24 Pochard F, Azoulay E, Chevret S, Lemaire F, Hubert P, Canoui P, et al.; French FAMIREA Group. Symptoms of anxiety and depression in family members of intensive care unit patients: ethical hypothesis regarding decision-making capacity. Crit Care Med. 2001;29(10):1893–7. doi:. http://dx.doi.org/10.1097/00003246-200110000-00007 PubMed
25 Kentish-Barnes N, Chaize M, Seegers V, Legriel S, Cariou A, Jaber S, et al.Complicated grief after death of a relative in the intensive care unit. Eur Respir J. 2015;45(5):1341–52. doi:. http://dx.doi.org/10.1183/09031936.00160014 PubMed
26 Azoulay E, Pochard F, Kentish-Barnes N, Chevret S, Aboab J, Adrie C, et al.; FAMIREA Study Group. Risk of post-traumatic stress symptoms in family members of intensive care unit patients. Am J Respir Crit Care Med. 2005;171(9):987–94. doi:. http://dx.doi.org/10.1164/rccm.200409-1295OC PubMed
27 Zimmerli M, Tisljar K, Balestra GM, Langewitz W, Marsch S, Hunziker S. Prevalence and risk factors for post-traumatic stress disorder in relatives of out-of-hospital cardiac arrest patients. Resuscitation. 2014;85(6):801–8. doi:. http://dx.doi.org/10.1016/j.resuscitation.2014.02.022 PubMed
28 Lautrette A, Darmon M, Megarbane B, Joly LM, Chevret S, Adrie C, et al.A communication strategy and brochure for relatives of patients dying in the ICU. N Engl J Med. 2007;356(5):469–78. doi:. http://dx.doi.org/10.1056/NEJMoa063446 PubMed
29 Curtis JR, Patrick DL, Shannon SE, Treece PD, Engelberg RA, Rubenfeld GD. The family conference as a focus to improve communication about end-of-life care in the intensive care unit: opportunities for improvement. Crit Care Med. 2001;29(2, Suppl):N26–33. doi:. http://dx.doi.org/10.1097/00003246-200102001-00006 PubMed
30 Curtis JR, Engelberg RA, Wenrich MD, Shannon SE, Treece PD, Rubenfeld GD. Missed opportunities during family conferences about end-of-life care in the intensive care unit. Am J Respir Crit Care Med. 2005;171(8):844–9. doi:. http://dx.doi.org/10.1164/rccm.200409-1267OC PubMed
32 Gauthier DM, Swigart VA. The contextual nature of decision making near the end of life: hospice patients’ perspectives. Am J Hosp Palliat Care. 2003;20(2):121–8. doi:. http://dx.doi.org/10.1177/104990910302000210 PubMed
33 Detering KM, Hancock AD, Reade MC, Silvester W. The impact of advance care planning on end of life care in elderly patients: randomised controlled trial. BMJ. 2010;340(mar23 1):c1345. doi:. http://dx.doi.org/10.1136/bmj.c1345 PubMed
34 Michiels E, Deschepper R, Van Der Kelen G, Bernheim JL, Mortier F, Vander Stichele R, et al.The role of general practitioners in continuity of care at the end of life: a qualitative study of terminally ill patients and their next of kin. Palliat Med. 2007;21(5):409–15. doi:. http://dx.doi.org/10.1177/0269216307078503 PubMed
35 Ramsaroop SD, Reid MC, Adelman RD. Completing an advance directive in the primary care setting: what do we need for success?J Am Geriatr Soc. 2007;55(2):277–83. doi:. http://dx.doi.org/10.1111/j.1532-5415.2007.01065.x PubMed
36 Tung EE, North F. Advance care planning in the primary care setting: a comparison of attending staff and resident barriers. Am J Hosp Palliat Care. 2009;26(6):456–63. doi:. http://dx.doi.org/10.1177/1049909109341871 PubMed
37 Emanuel LL. Advance directives. Annu Rev Med. 2008;59(1):187–98. doi:. http://dx.doi.org/10.1146/annurev.med.58.072905.062804 PubMed
38 Vilpert S, Borrat-Besson C, Maurer J, Borasio GD. Awareness, approval and completion of advance directives in older adults in Switzerland. Swiss Med Wkly. 2018;148:w14642. doi:. http://dx.doi.org/10.4414/smw.2018.14642 PubMed
39 Holley JL, Hines SC, Glover JJ, Babrow AS, Badzek LA, Moss AH. Failure of advance care planning to elicit patients’ preferences for withdrawal from dialysis. Am J Kidney Dis. 1999;33(4):688–93. doi:. http://dx.doi.org/10.1016/S0272-6386(99)70220-9 PubMed
40 Teno JM, Licks S, Lynn J, Wenger N, Connors AF, Phillips RS, et al.; Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatment. Do advance directives provide instructions that direct care? SUPPORT Investigators. J Am Geriatr Soc. 1997;45(4):508–12. doi:. http://dx.doi.org/10.1111/j.1532-5415.1997.tb05179.x PubMed
41 Brinkman-Stoppelenburg A, Rietjens JA, van der Heide A. The effects of advance care planning on end-of-life care: a systematic review. Palliat Med. 2014;28(8):1000–25. doi:. http://dx.doi.org/10.1177/0269216314526272 PubMed
42 Fromme EK, Zive D, Schmidt TA, Olszewski E, Tolle SW. POLST Registry do-not-resuscitate orders and other patient treatment preferences. JAMA. 2012;307(1):34–5. doi:. http://dx.doi.org/10.1001/jama.2011.1956 PubMed
43 Field RA, Fritz Z, Baker A, Grove A, Perkins GD. Systematic review of interventions to improve appropriate use and outcomes associated with do-not-attempt-cardiopulmonary-resuscitation decisions. Resuscitation. 2014;85(11):1418–31. doi:. http://dx.doi.org/10.1016/j.resuscitation.2014.08.024 PubMed
44 Stacey D, Légaré F, Lewis K, Barry MJ, Bennett CL, Eden KB, et al.Decision aids for people facing health treatment or screening decisions. Cochrane Database Syst Rev. 2017;4:CD001431. doi:. http://dx.doi.org/10.1002/14651858.CD001431.pub5 PubMed
45 Butler M, Ratner E, McCreedy E, Shippee N, Kane RL. Decision aids for advance care planning: an overview of the state of the science. Ann Intern Med. 2014;161(6):408–18. doi:. http://dx.doi.org/10.7326/M14-0644 PubMed
46 Becker C, Lecheler L, Hochstrasser S, Metzger KA, Widmer M, Thommen EB, et al.Association of Communication Interventions to Discuss Code Status With Patient Decisions for Do-Not-Resuscitate Orders: A Systematic Review and Meta-analysis. JAMA Netw Open. 2019;2(6):e195033. doi:. http://dx.doi.org/10.1001/jamanetworkopen.2019.5033 PubMed
47 Huynh TN, Kleerup EC, Wiley JF, Savitsky TD, Guse D, Garber BJ, et al.The frequency and cost of treatment perceived to be futile in critical care. JAMA Intern Med. 2013;173(20):1887–94. doi:. http://dx.doi.org/10.1001/jamainternmed.2013.10261 PubMed
49 Barjaktarevic I, Bobe L, Klapholz A, Dinan W. Multiple Cardiopulmonary Resuscitation Attempts in a Community Hospital: Evaluation of the Futility Assessment. Am J Hosp Palliat Care. 2015;32(5):504–9. doi:. http://dx.doi.org/10.1177/1049909114525258 PubMed
50 Perkins GD, Griffiths F, Slowther AM, George R, Fritz Z, Satherley P, et al. Do-not-attempt-cardiopulmonary-resuscitation decisions: an evidence synthesis. Southampton (UK): NIHR Journals Library; 2016.
52 Simon JR, Kraus C, Rosenberg M, Wang DH, Clayborne EP, Derse AR. “Futile Care”-An Emergency Medicine Approach: Ethical and Legal Considerations. Ann Emerg Med. 2017;70(5):707–13. doi:. http://dx.doi.org/10.1016/j.annemergmed.2017.06.005 PubMed
53 Curtis JR, Park DR, Krone MR, Pearlman RA. Use of the medical futility rationale in do-not-attempt-resuscitation orders. JAMA. 1995;273(2):124–8. doi:. http://dx.doi.org/10.1001/jama.1995.03520260046031 PubMed
55 Saltbaek L, Michelsen HM, Nelausen KM, Gut R, Nielsen DL. Old age and poor prognosis increase the likelihood of disagreement between cancer patients and their oncologists on the indication for resuscitation attempt. Support Care Cancer. 2013;21(12):3363–70. doi:. http://dx.doi.org/10.1007/s00520-013-1916-2 PubMed
56 Osinski A, Vreugdenhil G, de Koning J, van der Hoeven JG. Do-not-resuscitate orders in cancer patients: a review of literature. Support Care Cancer. 2017;25(2):677–85. doi:. http://dx.doi.org/10.1007/s00520-016-3459-9 PubMed
57 Reisfield GM, Wallace SK, Munsell MF, Webb FJ, Alvarez ER, Wilson GR. Survival in cancer patients undergoing in-hospital cardiopulmonary resuscitation: a meta-analysis. Resuscitation. 2006;71(2):152–60. doi:. http://dx.doi.org/10.1016/j.resuscitation.2006.02.022 PubMed
58 Ebell MH, Afonso AM. Pre-arrest predictors of failure to survive after in-hospital cardiopulmonary resuscitation: a meta-analysis. Fam Pract. 2011;28(5):505–15. doi:. http://dx.doi.org/10.1093/fampra/cmr023 PubMed
59 Girotra S, Nallamothu BK, Spertus JA, Li Y, Krumholz HM, Chan PS; American Heart Association Get with the Guidelines–Resuscitation Investigators. Trends in survival after in-hospital cardiac arrest. N Engl J Med. 2012;367(20):1912–20. doi:. http://dx.doi.org/10.1056/NEJMoa1109148 PubMed
61 George AL, Folk BP, Crecelius PL, Campbell WB. Pre-arrest morbidity and other correlates of survival after in-hospital cardiopulmonary arrest. Am J Med. 1989;87(1):28–34. doi:. http://dx.doi.org/10.1016/S0002-9343(89)80479-6 PubMed
62 Ebell MH. Prearrest predictors of survival following in-hospital cardiopulmonary resuscitation: a meta-analysis. J Fam Pract. 1992;34(5):551–8. PubMed
63 Bowker L, Stewart K. Predicting unsuccessful cardiopulmonary resuscitation (CPR): a comparison of three morbidity scores. Resuscitation. 1999;40(2):89–95. doi:. http://dx.doi.org/10.1016/S0300-9572(99)00008-8 PubMed
64 O’Keeffe S, Ebell MH. Prediction of failure to survive following in-hospital cardiopulmonary resuscitation: comparison of two predictive instruments. Resuscitation. 1994;28(1):21–5. doi:. http://dx.doi.org/10.1016/0300-9572(94)90050-7 PubMed
65 Piscator E, Göransson K, Bruchfeld S, Hammar U, El Gharbi S, Ebell M, et al.Predicting neurologically intact survival after in-hospital cardiac arrest-external validation of the Good Outcome Following Attempted Resuscitation score. Resuscitation. 2018;128:63–9. doi:. http://dx.doi.org/10.1016/j.resuscitation.2018.04.035 PubMed
66 Ebell MH, Jang W, Shen Y, Geocadin RG; Get With the Guidelines–Resuscitation Investigators. Development and validation of the Good Outcome Following Attempted Resuscitation (GO-FAR) score to predict neurologically intact survival after in-hospital cardiopulmonary resuscitation. JAMA Intern Med. 2013;173(20):1872–8. doi:. http://dx.doi.org/10.1001/jamainternmed.2013.10037 PubMed
67 Thai TN, Ebell MH. Prospective validation of the Good Outcome Following Attempted Resuscitation (GO-FAR) score for in-hospital cardiac arrest prognosis. Resuscitation. 2019;140:2–8. doi:. http://dx.doi.org/10.1016/j.resuscitation.2019.05.002 PubMed
68 Rubins JB, Kinzie SD, Rubins DM. Predicting Outcomes of In-Hospital Cardiac Arrest: Retrospective US Validation of the Good Outcome Following Attempted Resuscitation Score. J Gen Intern Med. 2019;34(11):2530–5. doi:. http://dx.doi.org/10.1007/s11606-019-05314-x PubMed
69 Ohlsson MA, Kennedy LM, Ebell MH, Juhlin T, Melander O. Validation of the good outcome following attempted resuscitation score on in-hospital cardiac arrest in southern Sweden. Int J Cardiol. 2016;221:294–7. doi:. http://dx.doi.org/10.1016/j.ijcard.2016.06.146 PubMed
70 Piscator E, Göransson K, Forsberg S, Bottai M, Ebell M, Herlitz J, et al.Prearrest prediction of favourable neurological survival following in-hospital cardiac arrest: The Prediction of outcome for In-Hospital Cardiac Arrest (PIHCA) score. Resuscitation. 2019;143:92–9. doi:. http://dx.doi.org/10.1016/j.resuscitation.2019.08.010 PubMed
Published under the copyright license
“Attribution – Non-Commercial – NoDerivatives 4.0”.
No commercial reuse without permission.