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Viewpoint

Vol. 150 No. 1718 (2020)

An independent appraisal and re-analysis of hydroxychloroquine treatment trial for COVID-19

  • Katheron Intson
  • Sachin A. Kumar
  • Amy Botta
  • Rachael Neckels
  • Connie Leung
  • Ali Jawaid
DOI
https://doi.org/10.4414/smw.2020.20262
Cite this as:
Swiss Med Wkly. 2020;150:w20262
Published
29.04.2020

References

  1. Gautret P, Lagier JC, Parola P, Hoang VT, Meddeb L, Mailhe M, et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int J Antimicrob Agents. 2020;105949. doi:.https://doi.org/10.1016/j.ijantimicag.2020.105949
  2. Schrezenmeier E, Dörner T. Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology. Nat Rev Rheumatol. 2020;16(3):155–66. doi:.https://doi.org/10.1038/s41584-020-0372-x
  3. Laboratory Corporation of America. 2020. https://www.fda.gov/media/136151/download
  4. Center for Disease Control and Prevention. 2020. https://www.fda.gov/media/134922/download
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  8. World Health Organization. 2020. https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200407-sitrep-78-covid-19.pdf?sfvrsn=bc43e1b_2
  9. Liu J, Cao R, Xu M, Wang X, Zhang H, Hu H, et al. Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro. Cell Discov. 2020;6(1):16. doi:.https://doi.org/10.1038/s41421-020-0156-0
  10. Yao X, Ye F, Zhang M, Cui C, Huang B, Niu P, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020;ciaa237. doi:.https://doi.org/10.1093/cid/ciaa237
  11. Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020;30(3):269–71. doi:.https://doi.org/10.1038/s41422-020-0282-0
  12. Cortegiani A, Ingoglia G, Ippolito M, Giarratano A, Einav S. A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19. J Crit Care. 2020;S0883-9441(20)30390-7. doi:.https://doi.org/10.1016/j.jcrc.2020.03.005
  13. Gao J, Tian Z, Yang X. Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies. Biosci Trends. 2020;14(1):72–3. doi:.https://doi.org/10.5582/bst.2020.01047
  14. Chen J, et al. A pilot study of hydroxychloroquine in treatment of patients with common coronavirus disease-19 (COVID-19). Journal of ZheJiang University (Medical Sciences). 2020.

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