a Clinic for Transplant Immunology and Nephrology, University Hospital Basel, Switzerland
b Division of Nephrology, Kantonsspital Baselland, Liestal, Switzerland
c Department of Nephrology, Hypertension and Clinical Pharmacology, University Hospital Bern, Inselspital, Switzerland
d Service of Nephrology, University Hospital of Geneva, Switzerland
e Department of Visceral Surgery, Centre Hospitalier Universitaire Vaudois, CHUV, University Hospital of Lausanne, Switzerland
f Department of Nephrology, University Hospital of Zurich, Switzerland
g Nephrology and Transplantation medicine, Kantonsspital St. Gallen, Switzerland
h Swiss Organ Living Donor Health Registry, University Hospital of Basel, Switzerland
We evaluated the prospectively collected data about the incidence of early peri- and postoperative complications, and potential risk factors for adverse outcomes after living kidney donation in Switzerland.
Peri- and postoperative events were prospectively recorded on a questionnaire by the local transplant teams of all Swiss transplant centres and evaluated by the Swiss Organ Living Donor Health Registry. Complications were classified according to the Clavien grading system. A total of 1649 consecutive donors between 1998 and 2015 were included in the analysis.
There was no perioperative mortality observed. The overall complication rate was 13.5%. Major complications defined as Clavien ≥3 occurred in 2.1% of donors. Obesity was not associated with any complications. Donor age >70years was associated with major complications (odds ratio [OR] 3.99) and genitourinary complications (urinary tract infection OR 5.85; urinary retention OR 6.61). There were more major complications observed in donors with laparoscopic surgery versus open surgery (p = 0.048), but an equal overall complication rate (p = 0.094).
We found a low rate of major and minor complications, independent of surgical technique, after living donor nephrectomy. There was no elevated complication rate in obese donors. In contrast, elderly donors >70 years had an elevated risk for perioperative complications.
Keywords: living donor nephrectomy, early complications, kidney transplantation, morbidity, donor registry
Kidney transplantation is considered the optimal treatment in patients with end-stage renal disease. Despite efforts to increase the number of deceased donors, the demand for renal transplantation exceeds the available organs by far. This shortage has led to an increase of kidney transplantations from living donors during the last decades. Living kidney donation (LKD) in Switzerland has been performed since the beginning of kidney transplantation in 1966. The percentage of kidney transplants from living donors has steadily increased and nowadays accounts for about one third of all donors in Switzerland [1, 2]. Living kidney donation has several advantages for the kidney recipient like improved long-term allograft survival, pre-emptive transplantation or shorter time on dialysis and therefore improved patient survival [3–5]. Ethical concerns about this procedure have existed since the very beginning of living kidney transplantation (LKT), as a healthy individual is exposed to the risk of a surgical procedure without a direct health benefit for him- or herself. In addition, selection criteria of living kidney donors have changed over time and nowadays some elderly, overweight or hypertensive donors are also accepted, with higher short- and long-term risks of complications [6, 7]. Therefore, detailed information about the risk of LKD is crucial to justify this procedure. Potential future donors must be better informed so that they fully understand the potential risk and long-term consequences associated with such a procedure. Despite the increase of LKD during past decades there are only a few articles reporting prospectively collected cohort data about perioperative, short-term and long-term complications after living donor nephrectomy [8–11]. Owing to the complete lack of such data in the early nineties, the Swiss Organ Living Donor Health Registry (SOL-DHR) was founded in 1993 with the aim to prospectively assess the incidence of complications of LKD and to identify risk profiles associated with unfavourable outcomes . We analysed the data from the SOL-DHR in terms of the incidence of early peri- and postoperative complications after LKD and potential risk factors for adverse outcome.
Materials and methods
Since 1993, all living kidney donors in Switzerland have been registered in a national registry, the SOL-DHR. Initially, all six kidney transplantation centres agreed to include all donors in the SOL-DHR and since 2007 it has been mandatory in accordance with Swiss transplantation law to provide a lifelong follow-up of all living donors in Switzerland. Since 1998, all six Swiss transplant centres (Basel, Berne, Geneva, Lausanne, St Gallen, Zurich) report the peri- and postoperative surgical complications to the SOL-DHR by filling in a questionnaire. For this study all patients who are registered in the SOL-DHR database with available data on the peri- and postoperative surgical complications from January 1998 until December 2015 were included.
Preoperative data consisted of height, weight, blood pressure, body mass index (BMI), sex, age and any medication. Peri- and postoperative events were reported by the local transplant team and recorded in a questionnaire (appendix 1, available in a separate file for downloading) consisting of following data: surgical complications, wound infections, urinary tract infections (UTI), other infections, urinary retention, deep vein thrombosis, pulmonary embolism, psychological complications, arterial hypertension after surgery on at least 2 consecutive days, need for blood transfusion, length of hospital stay, analgesic medication at discharge, other complications, side of nephrectomy, surgical technique, re-operation during the first 3 months, overall pain perception on visual analogue scale. The questionnaire was completed at the time of the donor discharge after nephrectomy and sent to the SOL-DHR. In addition, early complications during the first 3 months after surgery, which were reported to the SOL-DHR by the donors’ general practitioners or by the donors themselves, were included after evaluation and confirmation by the medical staff of the SOL-DHR.
Every early complication observed in a donor was classified by the medical board of the SOL-DHR according to the Dindo-Clavien grading system for surgical complications . Grade 1 is any deviation from the normal postoperative course that requires no treatment other than antiemetic, antipyretic, diuretic or analgesic medication, electrolytes or physiotherapy. Grade 2 requires medical therapy other than that allowed for in Grade 1. Grade 3 requires endoscopic, surgical or radiological interventions under local (3a) or general anaesthesia (3b). Grade 4 signifies failure in at least one organ system and is life threatening, requiring intensive care. Grade 5 equals death of the patient. Each complication was counted separately: one donor could present with several complications independent of each other, so each donor could contribute several times to a complication subtype.
During the study period, five different surgical techniques for LKD were performed. Classic open nephrectomy (OLDN) was used in the early period, fully laparoscopic nephrectomy (LDN) was introduced in 1997, hand-assisted laparoscopic nephrectomy (HLDN) in 1998, mini-incision pararectal nephrectomy (MLDN) in 1999 and retroperitoneoscopic nephrectomy (RLDN) in 2001. For the analysis of the influence of surgical technique on complications, two surgical categories were defined, either open (OLDN + MLDN) or laparoscopic (LDN, HLDN and RLDN).
The protocol was approved by the institutional ethics committees of the University of Basel, University of Berne, University of Geneva, University of Lausanne, Kantonsspital St. Gallen and University of Zurich, Switzerland.
We used JMP software version 12 (SAS Institute Inc., Cary, NC) for statistical analysis. Categorical data as given as count (percentage) and analysed with Pearson’s chi-square or Fisher’s exact test. Continuous data are given as median (interquartile range [IQR]) and were analysed with the Wilcoxon or Student’s t-test as appropriate. Odds ratios were calculated by comparing the frequency of the investigated outcome between two groups. As only three comparisons for each outcome were made, no correction for multiple testing was considered necessary. A p-value <0.05 was taken to indicate statistical significance.
From January 1998 to December 2015, 1694 living kidney donors were registered in the SOL-DHR. Data on peri- and postsurgical complications were available in 1649 of kidney donors (97.4%). Baseline characteristic are summarised in table 1. Duration of the hospital stay changed significantly over time, from a median of 10 days (IQR 8.25–11.75) in 1998 to 5 days (IQR 4–6) after 2012 (p <0.0001). During the study period, there were five different surgical types of donor nephrectomy performed (table 2). No perioperative mortality was observed during the study period. Overall there were 254 complications in 222 patients (13.5%) reported to the SOL-DHR and summarised in table 3. The overall rate of donors with severe complications (Clavien 3 and 4) was 2.1% (n = 34). Twenty donors needed a reoperation, 17 during the early postoperative period and 3 donors after discharge and within the first 3 months after nephrectomy. In eight donors reoperation was due to bleeding complications (seven with severe retroperitoneal hematoma and one with a lesion of the internal iliac artery). Other reasons for reoperation were hernia (n = 2), bowel perforation (n = 2) and mechanical ileus (n = 2). Conversion to OLDN was necessary in ten donors (seven LDN, one HLDN and in two RLDN). The incidence of severe complications (Clavien 3 and 4) was more frequent in donors undergoing laparoscopic techniques for nephrectomy than with open surgery (p = 0.048), but the overall complication rate, as well as the incidence of reoperation, were similar between the two surgical categories (p = 0.094 and p = 0.15 respectively). Age was significantly associated with severe complications (Clavien 3 and 4) when comparing donors aged >70 years with donors aged <50 years (OR 3.99, 95% CI 1.37 -11.67) (table 4). There was no association for donors with higher BMI (BMI <30 kg/m2 vs 30–35 kg/m2, p = 0.41; BMI <30 kg/m2 vs BMI >35 kg/m2, p = 0.52). In total, 17 donors (1.03%) received blood transfusions because of significant blood loss.
|BMI (kg/m2), median (IQR)||1637||25.0 (22.8–27.8)|
|BMI 30–35 kg/m2, n (%)||168 (10.3)|
|BMI >35 kg/m2, n (%)||19 (1.2)|
|Age (years), median (range)||1649||52.3 (21.6–80.0)|
|21–30 years, n (%)||63 (3.8)|
|31–40 years, n (%)||238 (14.4)|
|41–50 years, n (%)||453 (27.5)|
|51–60 years, n (%)||508 (30.8)|
|61–70 years, n (%)||329 (20.0)|
|71–80 years, n (%)||58 (3.5)|
|Right kidney (%)||1252||30.9%|
|Creatinine (μmol/l), median (IQR)||1620||67 (58–77)|
|GFR (ml/min/1.73m2), median (IQR)||1620||115.5 (99.0–134.3)|
|Arterial hypertension (%)||1386||18.3%|
|Pararectal mini-incision nephrectomy||121||7.4%|
|Hand assisted laparoscopic nephrectomy||569||34.5%|
|Pulmonary embolism||Reanimation with ICU admission with full recovery||1|
|Myocardial infarction||NSTEMI with ICU admission||1|
|Aortical lesion||life threatening intraoperative bleeding||1|
|Hernia||Reoperation (1 inguinal, 1 incisional)||2|
|Small bowel perforation||Reoperation||2|
|Mechanical ileus||Reoperation (1 ileum resection)||2|
|Testicular torsion||Reoperation with orchiectomy||1|
|Benign prostatic hyperplasia with recurrent urinary retention||Reoperation with TURP||1|
|Arterial lesion||Renal arterial branch (intraoperative), internal iliac artery (reoperation)||2|
|Chylous leakage||Percutaneous drainage||4|
|Pulmonary oedema||ICU admission and loop diuretics||1|
|Urinary tract infection||43|
|Septicaemia||Venous line associated||3|
|Other infections||Requiring antibiotics||15|
|Acute hepatitis||Drug related||1|
|Paralytic ileus||Prolonged ileus > 2 days||6|
|Haematoma||Requiring blood transfusion||12|
|Allergic reaction||2 antibiotic associated, 3 unknown reasons||5|
|Bronchospasm post-surgery||Known asthma||2|
|Cardiac arrhythmia||1 atrial fibrillation, 1 AV re-entry tachycardia||2|
|Other genitourinary disorders||3 hydrocele, 1 macrohaematuria, 1 penis ulcer||5|
|Chylous leakage||Without further intervention||7|
|Pneumothorax||Without chest drain||6|
|Severe haematoma||No blood transfusion or intervention||10|
|Secondary wound healing||Bedside wound opening day 2||1|
|Severe vomitus||≥ 2 days||10|
|Intraoperative positioning related complication||6 rhabdomyolysis, 1 severe shoulder pain,|
3 nerve lesion, 1 costal fracture
|Anaesthesia related complication||1 teeth damage, 1 glottis lesion, 1 keratitis, 3 venous line related phlebitis||6|
|Allergic skin reaction||No treatment||5|
|Severe skin emphysema||After retroperitoneoscopic nephrectomy||1|
|Retained needle||No further intervention as asymptomatic||1|
|Overall total n||254|
|Age group||Odds ratio||95% confidence interval||p-value|
Grade 2 complications were mainly infectious diseases (see table 3). UTI was significantly associated with older age (table 5). There were no associations between the incidence of wound infections and a higher BMI (BMI <30 kg/m2 vs BMI >30 kg/m2, p = 0.54) or between open versus laparoscopic nephrectomy (p = 0.76). Urinary retention was more frequently observed in male than in female donors (17/559 vs 11/1062, p = 0.008) and in donors aged >70 years compared to donors aged <50 years (OR 6.61, 95% CI 2.29–19.11) (table 6). At the day of discharge 66.8% of donors still took some analgesic drugs.
|Age group||Odds ratio||95% confidence interval||p-value|
|Age group||Odds ratio||95% confidence interval||p–value|
During the postoperative phase 73 donors (4.4%) had hypertensive blood pressure readings (>140/90 mm Hg) on at least two consecutive days. Of these, 49 donors were already treated for hypertension. For 11 donors, blood pressure normalised during follow-up; 13 donors had persistent hypertension and had to start antihypertensive medication.
Psychological disorders (depression, anxiety) were observed in 44 donors (2.7%). There was no centre effect for the overall rate of all the different categories of complications (p = 0.24).
During the study period, there was no perioperative mortality in 1694 consecutive living donor nephrectomies. Historically, not a single donor has died as a consequence of the nephrectomy since the beginning of LKD in Switzerland in 1966 . In the literature the overall LKD specific mortality is known to be between 0.03% and 0.04% [11, 15]. Overall, there were 254 complications in 222 donors (13.5%) observed during the study period. This complication rate is similar to those reported in the literature, with a rate of 7.9 to 20.9% [8, 16–19]. Severe postoperative complications (Clavien 3 and 4) were seen in 2.1% of donors compared with 2.9% to 7.3% in previous publications [8, 17, 18]. We found a significant association between severe complications (Clavien 3 and 4) and donor age (>70 years vs <50 years) and the laparoscopic surgical approaches. Similar findings were reported by Lentine and co-workers, who found a higher incidence of all grades of complications with increasing age at donation (adjusted OR 1.01, 95% CI 1.01–1.02)  and by the Norwegian Registry , which showed a significant association between laparoscopic nephrectomy and major complications with an OR of 2.01. This result might be explained by a learning curve after introduction of the new laparoscopic surgical techniques, as has been reported by several groups [8, 20]. But after analysing the overall complication rates by surgical technique, we could not find any difference between open and laparoscopic nephrectomy (p = 0.094).
Twenty donors needed a reoperation. The most common reasons were bleeding complications (n = 8) and bowel complications (n = 5). In 10 donors, the laparoscopic surgical approach was converted to OLDN, in two of these patients because of severe intraoperative bleeding. Mjoen et al reported intraoperative bleeding complications in 14/1022 donors, with necessary conversion to open surgery in 3/14 ; even fatal haemorrhage has occurred [21, 22].
Chylous leakage was observed in 13 donors (0.8%), three of whom needed reoperation and four an intervention with percutaneous drainage of the chyle, with our without a low fat medium-chain triglyceride diet and octreotide application for resolving of the chylous leakage. The highest rate of chylous drainage after LDN in the literature was reported by Capocasale et al., at 3.8% of donor . The chylous leakage in their series was solely observed in donors with left sided LDN, which was also the case in our series. This complication is left-side dependent because of the root of the mesentery and the presence of the left ascending lumbar trunk in the area of surgical dissection. We could not find a relation between the occurrence of chylous leakage and nephrectomy techniques (open vs laparoscopic) (p = 0.31).
There are a large number of publications comparing the complication rate of different kinds of surgical techniques. In two large systematic reviews and one meta-analysis the authors could not find a significant difference between the different surgical techniques with regard to the overall early intra- and perioperative complication rates [24–26]. These data suggest that there is no substantial difference between the applied surgical techniques in terms of early complication rate. In general, laparoscopic nephrectomy is more often used nowadays because it is associated with less pain after surgery, shorter hospital stay and faster return to work [27–29].
Donor obesity is always a concern, not only in terms of onset of metabolic syndrome after kidney donation with its risk of end-stage renal disease, but also in terms of perioperative complication rates. During past decades more and more obese donors were accepted for donation . In our study, we did not find an association between obese donors (BMI >30 kg/m2; 11.5% of the study population) and early complications of any kind. Whether this holds true for very obese donors (BMI >35 or >40 kg/m2) is unclear as only 1.2% of our study population had a BMI >35 kg/m2. Mjoen also found no association with perioperative bleeding and/or intraoperative incidents in their 8.3% obese donors with a BMI >30 kg/m2 . O’Brien reported an overall equal early complication rate in obese patients (25.6% of their study population) in a series of 383 donor nephrectomies, but a higher incidence of respiratory complications in a subgroup analysis of patient with a BMI >40 kg/m2 . Schold et al., in a large US registry study, did not find any association between obesity and procedure-related complications in more than 69 000 donor nephrectomies . These data are in contrast to the registry-based studies from Friedman et al. and Patel et al., who reported a higher incidence of donor complications in obese patients with ORs of 1.76 and 1.92, respectively [16, 18]. Overall, the available data and our experience suggest an acceptable safety of nephrectomy in obese patient, with low levels of severe early complications across all BMI categories, but long-term surveillance of new onset of arterial hypertension or diabetes is mandatory when obese patients are accepted for donation.
Infectious diseases after donation were the most frequent Grade 2 complication, with a high rate of clinical UTI (2.6%). In contrast, Mjoen et al  found a much higher incidence of UTI (10.1%). But in their study, donors were systematically screened postoperatively with urine culture for UTI without differentiation between asymptomatic bacteriuria and clinical UTI. So there might be an overestimation of UTI in their study. We assume that the higher rate of urinary retention observed in male elderly donors is due to an underlying prostatic hyperplasia. We observed some complications associated with intraoperative positioning of the donor in 0.7%, as well as anaesthesia-related complication in 0.4% of donors. Data about the incidence of such complications in living donor nephrectomy are very rare in the literature, with only a few case reports of rhabdomyolysis after donor nephrectomy [31, 32]; this suggests an underreporting of such incidents.
Eighteen per cent of donors had a history of hypertension at the time of donation, which is comparable to other registries [7, 8]. During the hospitalisation, new onset hypertension was diagnosed in another 0.9% of donors. Previously published data from the SOL-DHR have shown that kidney donation increases the risk of hypertension after 1 year 3.64-fold  underlining the importance of close blood pressure surveillance after kidney donation.
The strengths of the current study are the prospective nature, standardisation, consistency and completeness of the data collected over 18 years on a nationwide basis, i.e., including every single consecutive donor within one country and resulting in a high number of donors included in the analysis. Data collection was very detailed and regular queries were made. In addition, each complication was confirmed by the medical staff of the SOL-DHR. Underreporting was further minimised by including complications reported to the SOL-DHR by the donors or their general practitioner. After confirmation these complication were included in the analysis.
However, there are also several limitations. Despite the very careful prospective collection of the complications on a standardised questionnaire, there remains a risk of underreporting of early complications and a lack of systematic review of donor charts and surgical reports. Secondly, the low frequency of major complications and intraoperative incidents limits multivariate analysis of several risk factors. Thirdly, there might be other risk factors not known and therefore not collected specifically by the SOL-DHR. However, patients had the possibility to mention any complication as free text on the form. Up to now, no clear complication or problem could be identified. Last, but not least, caution is necessary in extrapolating the low complication rates seen in our study to other cohorts without considering a potentially overall lower risk profile of our Swiss donor population.
In summary, our data confirm that living donor nephrectomy is a safe procedure with a low rate of major and minor complications, independent of surgical technique. We did not find a higher incidence of any complication in obese donors, which supports the policy of acceptance of obese individuals for donation. In contrast, we found a higher incidence of severe complications (Clavien 3 and 4) and genitourinary complications (UTI, urinary retention) in donors aged >70 years. It is mandatory to carefully inform older donors about their elevated perioperative risks. Furthermore, continuous prospective evaluation of donor complications by donor registries is crucial, to improve peri- and postoperative management and to detect any increase in risks, as donors with more comorbidities are accepted nowadays. Our results have prompted our Swiss working group for living donors to renew the documents for donors` general information accordingly.
We would like to thank the medical/surgical team of the Swiss Transplant centres for collecting the data. We would also like to thank Daniela Garzoni from the SOL-DHR for her help and support.
Participated in research design: J. Steiger
Participated in the writing of the paper: F. Burkhalter, I. Binet, U. Huynh-Do, M. Matter, TF. Mueller, C. Nolte, J. Steiger
Participated in the performance of the research: F. Burkhalter, J. Steiger, I. Binet, U. Huynh-Do, K. Hadaya, M. Matter, C. Nolte, TF. Mueller
Participated in data analysis: F. Burkhalter, C. Nolte
The study was sponsored by Viollier AG, Allschwil, Switzerland.
No potential conflict of interest relevant to this article was reported.
Felix Burkhalter, MD, Division of Nephrology, Kantonsspital Baselland, Rheinstrasse 26, CH-4410 Liestal, felix.burkhalter[at]ksbl.ch
1 Swiss Transplant cohort. Annual Report 2015; http://www.stcs.ch/research/publications.
3 Wehmeier C, Georgalis A, Hirt-Minkowski P, Amico P, Hoenger G, Voegele T, et al.2222 kidney transplantations at the University Hospital Basel: a story of success and new challenges. Swiss Med Wkly. 2016;146:w14317. PubMed
4 Abecassis M, Bartlett ST, Collins AJ, Davis CL, Delmonico FL, Friedewald JJ, et al.Kidney transplantation as primary therapy for end-stage renal disease: a National Kidney Foundation/Kidney Disease Outcomes Quality Initiative (NKF/KDOQITM) conference. Clin J Am Soc Nephrol. 2008;3(2):471–80. doi:https://doi.org/10.2215/CJN.05021107. http://dx.doi.org/10.2215/CJN.05021107 PubMed
5 Kasiske BL, Snyder JJ, Matas AJ, Ellison MD, Gill JS, Kausz AT. Preemptive kidney transplantation: the advantage and the advantaged. J Am Soc Nephrol. 2002;13(5):1358–64. doi:https://doi.org/10.1097/01.ASN.0000013295.11876.C9. http://dx.doi.org/10.1097/01.ASN.0000013295.11876.C9 PubMed
6 Taler SJ, Messersmith EE, Leichtman AB, Gillespie BW, Kew CE, Stegall MD, et al.; RELIVE Study Group. Demographic, metabolic, and blood pressure characteristics of living kidney donors spanning five decades. Am J Transplant. 2013;13(2):390–8. doi:https://doi.org/10.1111/j.1600-6143.2012.04321.x. http://dx.doi.org/10.1111/j.1600-6143.2012.04321.x PubMed
7 Clayton PA, Saunders JR, McDonald SP, Allen RD, Pilmore H, Saunder A, et al.Risk-Factor Profile of Living Kidney Donors: The Australia and New Zealand Dialysis and Transplant Living Kidney Donor Registry 2004-2012. Transplantation. 2016;100(6):1278–83. doi:https://doi.org/10.1097/TP.0000000000000877. http://dx.doi.org/10.1097/TP.0000000000000877 PubMed
8 Mjøen G, Øyen O, Holdaas H, Midtvedt K, Line PD. Morbidity and mortality in 1022 consecutive living donor nephrectomies: benefits of a living donor registry. Transplantation. 2009;88(11):1273–9. doi:https://doi.org/10.1097/TP.0b013e3181bb44fd. http://dx.doi.org/10.1097/TP.0b013e3181bb44fd PubMed
9 Janki S, Klop KW, Dooper IM, Weimar W, Ijzermans JN, Kok NF. More than a decade after live donor nephrectomy: a prospective cohort study. Transpl Int. 2015;28(11):1268–75. doi:https://doi.org/10.1111/tri.12589. http://dx.doi.org/10.1111/tri.12589 PubMed
10 Minnee RC, Bemelman WA, Polle SW, van Koperen PJ, Ter Meulen S, Donselaar-van der Pant KA, et al.Older living kidney donors: surgical outcome and quality of life. Transplantation. 2008;86(2):251–6. doi:https://doi.org/10.1097/TP.0b013e31817789dd. http://dx.doi.org/10.1097/TP.0b013e31817789dd PubMed
11 Hadjianastassiou VG, Johnson RJ, Rudge CJ, Mamode N. 2509 living donor nephrectomies, morbidity and mortality, including the UK introduction of laparoscopic donor surgery. Am J Transplant. 2007;7(11):2532–7. doi:https://doi.org/10.1111/j.1600-6143.2007.01975.x. http://dx.doi.org/10.1111/j.1600-6143.2007.01975.x PubMed
12 Thiel GT, Nolte C, Tsinalis D. Prospective Swiss cohort study of living-kidney donors: study protocol. BMJ Open. 2011;1(2):e000202. doi:https://doi.org/10.1136/bmjopen-2011-000202. http://dx.doi.org/10.1136/bmjopen-2011-000202 PubMed
13 Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205–13. doi:https://doi.org/10.1097/01.sla.0000133083.54934.ae. http://dx.doi.org/10.1097/01.sla.0000133083.54934.ae PubMed
14 Thiel GT, Nolte C, Tsinalis D. Das Schweizer Lebendspender-Gesundheitsregister (SOL-DHR) [The Swiss Organ Living Donor Health Registry (SOL-DHR)]. Ther Umsch. 2005;62(7):449–57. [Article in German] doi:https://doi.org/10.1024/0040-59220.127.116.119. http://dx.doi.org/10.1024/0040-5918.104.22.1689 PubMed
15 Segev DL, Muzaale AD, Caffo BS, Mehta SH, Singer AL, Taranto SE, et al.Perioperative mortality and long-term survival following live kidney donation. JAMA. 2010;303(10):959–66. doi:https://doi.org/10.1001/jama.2010.237. http://dx.doi.org/10.1001/jama.2010.237 PubMed
16 Friedman AL, Cheung K, Roman SA, Sosa JA. Early clinical and economic outcomes of patients undergoing living donor nephrectomy in the United States. Arch Surg. 2010;145(4):356–62, discussion 362. doi:https://doi.org/10.1001/archsurg.2010.17. http://dx.doi.org/10.1001/archsurg.2010.17 PubMed
17 Lentine KL, Lam NN, Axelrod D, Schnitzler MA, Garg AX, Xiao H, et al.Perioperative Complications After Living Kidney Donation: A National Study. Am J Transplant. 2016;16(6):1848–57. doi:https://doi.org/10.1111/ajt.13687. http://dx.doi.org/10.1111/ajt.13687 PubMed
18 Patel S, Cassuto J, Orloff M, Tsoulfas G, Zand M, Kashyap R, et al.Minimizing morbidity of organ donation: analysis of factors for perioperative complications after living-donor nephrectomy in the United States. Transplantation. 2008;85(4):561–5. doi:https://doi.org/10.1097/TP.0b013e3181643ce8. http://dx.doi.org/10.1097/TP.0b013e3181643ce8 PubMed
19 Schold JD, Goldfarb DA, Buccini LD, Rodrigue JR, Mandelbrot DA, Heaphy EL, et al.Comorbidity burden and perioperative complications for living kidney donors in the United States. Clin J Am Soc Nephrol. 2013;8(10):1773–82. doi:https://doi.org/10.2215/CJN.12311212. http://dx.doi.org/10.2215/CJN.12311212 PubMed
20 Ruszat R, Sulser T, Dickenmann M, Wolff T, Gürke L, Eugster T, et al.Retroperitoneoscopic donor nephrectomy: donor outcome and complication rate in comparison with three different techniques. World J Urol. 2006;24(1):113–7. doi:https://doi.org/10.1007/s00345-006-0051-9. http://dx.doi.org/10.1007/s00345-006-0051-9 PubMed
21 Friedman AL, Peters TG, Jones KW, Boulware LE, Ratner LE. Fatal and nonfatal hemorrhagic complications of living kidney donation. Ann Surg. 2006;243(1):126–30. doi:https://doi.org/10.1097/01.sla.0000193841.43474.ec. http://dx.doi.org/10.1097/01.sla.0000193841.43474.ec PubMed
22 Hartmann A, Fauchald P, Westlie L, Brekke IB, Holdaas H. The risk of living kidney donation. Nephrol Dial Transplant. 2003;18(5):871–3. doi:https://doi.org/10.1093/ndt/gfg069. http://dx.doi.org/10.1093/ndt/gfg069 PubMed
23 Capocasale E, Iaria M, Vistoli F, Signori S, Mazzoni MP, Dalla Valle R, et al.Incidence, diagnosis, and treatment of chylous leakage after laparoscopic live donor nephrectomy. Transplantation. 2012;93(1):82–6. doi:https://doi.org/10.1097/TP.0b013e31823b2d8e. http://dx.doi.org/10.1097/TP.0b013e31823b2d8e PubMed
24 Greco F, Hoda MR, Alcaraz A, Bachmann A, Hakenberg OW, Fornara P. Laparoscopic living-donor nephrectomy: analysis of the existing literature. Eur Urol. 2010;58(4):498–509. doi:https://doi.org/10.1016/j.eururo.2010.04.003. http://dx.doi.org/10.1016/j.eururo.2010.04.003 PubMed
25 Nanidis TG, Antcliffe D, Kokkinos C, Borysiewicz CA, Darzi AW, Tekkis PP, et al.Laparoscopic versus open live donor nephrectomy in renal transplantation: a meta-analysis. Ann Surg. 2008;247(1):58–70. doi:https://doi.org/10.1097/SLA.0b013e318153fd13. http://dx.doi.org/10.1097/SLA.0b013e318153fd13 PubMed
26 Wilson CH, Sanni A, Rix DA, Soomro NA. Laparoscopic versus open nephrectomy for live kidney donors. Cochrane Database Syst Rev. 2011;(11):CD006124. PubMed
27 Andersen MH, Mathisen L, Oyen O, Edwin B, Digernes R, Kvarstein G, et al.Postoperative pain and convalescence in living kidney donors-laparoscopic versus open donor nephrectomy: a randomized study. Am J Transplant. 2006;6(6):1438–43. doi:https://doi.org/10.1111/j.1600-6143.2006.01301.x. http://dx.doi.org/10.1111/j.1600-6143.2006.01301.x PubMed
28 Wolf JS, Merion RM, Leichtman AB, Campbell DA, Magee JC, Punch JD, et al.Randomized controlled trial of hand-assisted laparoscopic versus open surgical live donor nephrectomy. Transplantation. 2001;72(2):284–90. doi:https://doi.org/10.1097/00007890-200107270-00021. http://dx.doi.org/10.1097/00007890-200107270-00021 PubMed
29 Bachmann A, Wolff T, Giannini O, Dickenman M, Ruszat R, Gürke L, et al.How painful is donor nephrectomy? Retrospective analysis of early pain and pain management in open versus laparoscopic versus retroperitoneoscopic nephrectomy. Transplantation. 2006;81(12):1735–8. doi:https://doi.org/10.1097/01.tp.0000225800.69089.b4. http://dx.doi.org/10.1097/01.tp.0000225800.69089.b4 PubMed
30 O’Brien B, Mastoridis S, Sabharwal A, Hakim N, Taube D, Papalois V. Expanding the donor pool: living donor nephrectomy in the elderly and the overweight. Transplantation. 2012;93(11):1158–65. doi:https://doi.org/10.1097/TP.0b013e31824ef1ae. http://dx.doi.org/10.1097/TP.0b013e31824ef1ae PubMed
31 Kuang W, Ng CS, Matin S, Kaouk JH, El-Jack M, Gill IS. Rhabdomyolysis after laparoscopic donor nephrectomy. Urology. 2002;60(5):911. doi:https://doi.org/10.1016/S0090-4295(02)01911-8. http://dx.doi.org/10.1016/S0090-4295(02)01911-8 PubMed
32 van Dellen D, Tavakoli A, Wadsworth R, Augustine T. Intraoperative hyperkaliemia complicating hand-assisted live-donor nephrectomy. Exp Clin Transplant. 2011;9(6):417–20. PubMed
33 Thiel GT, Nolte C, Tsinalis D, Steiger J, Bachmann LM. Investigating kidney donation as a risk factor for hypertension and microalbuminuria: findings from the Swiss prospective follow-up of living kidney donors. BMJ Open. 2016;6(3):e010869. doi:https://doi.org/10.1136/bmjopen-2015-010869. http://dx.doi.org/10.1136/bmjopen-2015-010869 PubMed
Appendix 1: Questionnaire for reporting surgical complications to the SOL-DHR
The questionnaire is available as a separate file at https://smw.ch/en/article/doi/smw.2017.14497/
Published under the copyright license
“Attribution – Non-Commercial – NoDerivatives 4.0”.
No commercial reuse without permission.