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Original article

Vol. 146 No. 2728 (2016)

31 years of lung cancer in the canton of Zurich, Switzerland: incidence trends by sex, histology and laterality

  • Lisa Susanna Oberli
  • Fabio Valeri
  • Dimitri Korol
  • Sabine Rohrmann
  • Silvia Dehler
DOI
https://doi.org/10.4414/smw.2016.14327
Cite this as:
Swiss Med Wkly. 2016;146:w14327
Published
03.07.2016

Summary

QUESTIONS UNDER STUDY: Lung cancer belongs to the most common cancers in Switzerland. We examined trends in lung cancer incidence, with focus on sex, histology and laterality, in the Canton of Zurich since 1980.

MATERIAL AND METHODS: Registry data consisting of 16 798 lung cancer cases from 1980 to 2010 were analysed. Cases were classified into adenocarcinoma (ADC), squamous cell carcinoma (SCC), small-cell carcinoma (SCLC), large cell tumour and carcinoid tumour. Age-standardised (European standard) incidence rates (IR) per 100 000 person-years, male-to-female incidence-rate ratio (M/F-IRR), and left-to-right lung incidence-rate ratio (L/R-IRR) were calculated.

RESULTS: Over the study period, ADC occurred most frequently (31.9%), followed by SCC (29.1%), SCLC (15.4%), large cell carcinoma (6.3%), and carcinoid tumour (1.5%). Other/unspecified subtypes accounted for 15.7%. In men, the IR of SCC decreased from 34.2/100 000 (95% confidence interval [CI] 32.5–35.9) in 1980 to 12.8/100 000 (12.0–13.6) in 2010, but increased in women from 3.4/100 000 (2.7–4.0) to 4.0/100 000 (3.4–4.5). The IR of ADC increased in women from 5.1/100 000 (4.1–5.8) to 12.6/100 000 (11.8–13.4) and in men from 15.1/100 000 (14.0–16.3) to 19.4/100 000 (18.4–20.4). Overall M/F-IRR was 2.61; the highest ratio (5.8) was seen for SCC and the lowest (0.77) for carcinoid tumour. All histological subtypes showed a higher susceptibility of the right lung.

CONCLUSION: Our data reflect the global increase of lung cancer in women. ADC increased over time in women and men, whereas SCC decreased markedly among men. These trends may have occurred owing to changes in smoking behaviour and cigarette composition.

References

  1. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359–86.
  2. Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JW, Comber H, et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer. 2013;49(6):1374–403.
  3. Bundesamt für Statistik. Krebsmortalität: Todesfälle, Raten, Entwicklung, Medianalter, Risiko, pro Krebslokalisation. Neuchâtel: Bundesamt für Statistik Schweiz. Available from: http://www.bfs.admin.ch/bfs/portal/de/index/themen/14/02/05/key/01/02.html (accessed: 06. February 2016)
  4. Lortet-Tieulent J, Soerjomataram I, Ferlay J, Rutherford M, Weiderpass E, Bray F. International trends in lung cancer incidence by histological subtype: adenocarcinoma stabilizing in men but still increasing in women. Lung Cancer. 2014;84(1):13–22.
  5. Levi F, Franceschi S, La Vecchia C, Randimbison L, Te VC. Lung carcinoma trends by histologic type in Vaud and Neuchâtel, Switzerland, 1974–1994. Cancer. 1997;79(5):906–14.
  6. Roychoudhuri R, Putcha V, Møller H. Cancer and laterality: a study of the five major paired organs (UK). Cancer Causes Control. 2006;17(5):655–62.
  7. McGuire S. World Cancer Report 2014. Geneva, Switzerland: World Health Organization, International Agency for Research on Cancer, WHO Press, 2015. Adv Nutr. 2016;7(2):418–9.
  8. Jemal A, Thun MJ, Ries LA, Howe HL, Weir HK, Center MM, et al. Annual report to the nation on the status of cancer, 1975-2005, featuring trends in lung cancer, tobacco use, and tobacco control. J Natl Cancer Inst. 2008;100(23):1672–94.
  9. Li YJ, Tsai YC, Chen YC, Christiani DC. Human papilloma virus and female lung adenocarcinoma. Semin Oncol. 2009;36(6):542–52.
  10. Peto R, Lopez AD, Boreham J, Thun M, Heath C. Mortality from tobacco in developed countries: indirect estimation from national vital statistics. Lancet. 1992;339(8804):1268–78.
  11. Alberg AJ, Samet JM. Epidemiology of lung cancer. Chest. 2003;123(1 Suppl):21S–49S.
  12. Dela Cruz CS, Tanoue LT, Matthay RA. Lung cancer: epidemiology, etiology, and prevention. Clin Chest Med. 2011;32(4):605–44.
  13. Bray FI, Weiderpass E. Lung cancer mortality trends in 36 European countries: secular trends and birth cohort patterns by sex and region 1970–2007. Int J Cancer. 2010;126(6):1454–66.
  14. Gsell O. Rauchergewohnheiten der Ärzteschaft der Schweiz. Schweize Med Wochenschr.1956;23:669–75
  15. Abelin Th, Müller R. Trend der Rauchgewohnheiten in der Schweiz 1975–1981. Int J Public Health. 1983;28(3):185–95.
  16. Schweizerische Gesundheitsbefragung (SGB). Tabakkonsum nach Alter, Geschlecht, Sprachgebiet, Bildungsniveau,1992–2012. Neuchâtel: Bundesamt für Statistik. Available from: http://www.bfs.admin.ch/bfs/portal/de/index/themen/14/02/02/key/03.html (accessed: 05. January 2016)
  17. Roemer E, Schorp MK, Piadé JJ, Seeman JI, Leyden DE, Haussmann HJ. Scientific assessment of the use of sugars as cigarette tobacco ingredients: a review of published and other publicly available studies. Crit Rev Toxicol. 2012;42(3):244–78.
  18. Hoffmann D, Djordjevic MV, Hoffmann I. The changing cigarette. Prev Med. 1997;26(4):427–34.
  19. Islami F, Torre LA, Jemal A. Global trends of lung cancer mortality and smoking prevalence. Transl Lung Cancer Res. 2015;4(4):327–38.
  20. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin. 2012;62(1):10–29.
  21. Howlader N, Noone AM, Krapcho M, Miller D, Bishop K, Altekruse SF, et al. SEER cancer statistics review, 1975-2013. Bethesda, MD: National Cancer Institute. Available from: http://seer.cancer.gov/csr/1975_2013/ (accessed: 25. April 2016)
  22. Fritz A, Percy C, Jack A, Shanmugaratnam K, Sobin LH, Parkin DM, et al. International Classification of Diseases for Oncology. 3 ed. Geneva, Switzerland: World Health Organization; 2000.
  23. Doll R, Cook P. Summarizing indices for comparison of cancer incidence data. Int J Cancer. 1967;2(3):269–79.
  24. American Cancer Society. Cancer facts & figures 2014. Atlanta: American Cancer Society; 2014.
  25. Allemani C, Weir HK, Carreira H, Harewood R, Spika D, Wang XS, et al. Global surveillance of cancer survival 1995–2009: analysis of individual data for 25,676,887 patients from 279 population-based registries in 67 countries (CONCORD-2). Lancet. 2015;385(9972):977–1010.
  26. La Vecchia C, Levi F, Decarli A, Wietlisbach V, Negri E, Gutzwiller F. Trends in smoking and lung cancer mortality in Switzerland. Prev Med. 1988;17(6):712–24.
  27. Bosetti C, Malvezzi M, Rosso T, Bertuccio P, Gallus S, Chatenoud L, et al. Lung cancer mortality in European women: trends and predictions. Lung Cancer. 2012;78(3):171–8.
  28. Brenner H, Francisci S, de Angelis R, Marcos-Gragera R, Verdecchia A, Gatta G, et al. Long-term survival expectations of cancer patients in Europe in 2000–2002. Eur J Cancer. 2009;45(6):1028–41.
  29. Jemal A, Travis WD, Tarone RE, Travis L, Devesa SS. Lung cancer rates convergence in young men and women in the United States: analysis by birth cohort and histologic type. Int J Cancer. 2003;105(1):101–7.
  30. Howlader N, Noone A, Krapcho M, Garshell J, Miller D, Altekruse S, et al. SEER Cancer Statistics Review, 1975–2011. Bethesda, MD: National Cancer Institute; 2014.
  31. Lewis DR, Check DP, Caporaso NE, Travis WD, Devesa SS. US lung cancer trends by histologic type. Cancer. 2014;120(18):2883–92.
  32. Houston KA, Henley SJ, Li J, White MC, Richards TB. Patterns in lung cancer incidence rates and trends by histologic type in the United States, 2004–2009. Lung Cancer. 2014;86(1):22–8.
  33. Devesa SS, Shaw GL, Blot WJ. Changing patterns of lung cancer incidence by histological type. Cancer Epidemiol Biomarkers Prev. 1991;1(1):29–34.
  34. Travis WD, Lubin J, Ries L, Devesa S. United States lung carcinoma incidence trends: declining for most histologic types among males, increasing among females. Cancer. 1996;77(12):2464–70.
  35. Khuder SA. Effect of cigarette smoking on major histological types of lung cancer: a meta-analysis. Lung Cancer. 2001;31(2-3):139–48.
  36. U.S. Department of Health and Human Services. The health consequences of smoking: 50 years of progress. A report of the surgeon general. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health. 2014.
  37. Burns DM, Anderson CM, Gray N. Do changes in cigarette design influence the rise in adenocarcinoma of the lung? Cancer Causes Control. 2011;22(1):13–22.
  38. Kenfield SA, Wei EK, Stampfer MJ, Rosner BA, Colditz GA. Comparison of aspects of smoking among the four histological types of lung cancer. Tob Control. 2008;17(3):198–204.
  39. Stellman SD, Muscat JE, Thompson S, Hoffmann D, Wynder EL. Risk of squamous cell carcinoma and adenocarcinoma of the lung in relation to lifetime filter cigarette smoking. Cancer. 1997;80(3):382–8.
  40. Danaei G, Vander Hoorn S, Lopez AD, Murray CJ, Ezzati M, (Cancers) CRAcg. Causes of cancer in the world: comparative risk assessment of nine behavioural and environmental risk factors. Lancet. 2005;366(9499):1784–93.
  41. Thun MJ, Carter BD, Feskanich D, Freedman ND, Prentice R, Lopez AD, et al. 50-year trends in smoking-related mortality in the United States. N Engl J Med. 2013;368(4):351–64.
  42. Thun MJ, Lally CA, Flannery JT, Calle EE, Flanders WD, Heath CW. Cigarette smoking and changes in the histopathology of lung cancer. J Natl Cancer Inst. 1997;89(21):1580–6.
  43. Marti J. The impact of tobacco control expenditures on smoking initiation and cessation. Health Econ. 2014;23(12):1397–410.
  44. Otto B. Die Geschichte des Rauchens – wie Nichtrauchen wieder gesellschaftsfähig wird. Berne: Verlag Hans Huber, Hogrefe AG; 2010.
  45. Zang EA, Wynder EL. Differences in lung cancer risk between men and women: examination of the evidence. J Natl Cancer Inst. 1996;88(3-4):183–92.
  46. Begg CB, Zhang ZF, Sun M, Herr HW, Schantz SP. Methodology for evaluating the incidence of second primary cancers with application to smoking-related cancers from the Surveillance, Epidemiology, and End Results (SEER) program. Am J Epidemiol. 1995;142(6):653–65.
  47. Risch HA, Howe GR, Jain M, Burch JD, Holowaty EJ, Miller AB. Are female smokers at higher risk for lung cancer than male smokers? A case-control analysis by histologic type. Am J Epidemiol. 1993;138(5):281–93.
  48. Harris RE, Zang EA, Anderson JI, Wynder EL. Race and sex differences in lung cancer risk associated with cigarette smoking. Int J Epidemiol. 1993;22(4):592–9.
  49. Wynder EL, Muscat JE. The changing epidemiology of smoking and lung cancer histology. Environ Health Perspect. 1995;103(Suppl 8):143–8.
  50. Hebert JR, Kabat GC. Distribution of smoking and its association with lung cancer: implications for studies on the association of fat with cancer. J Natl Cancer Inst. 1991;83(12):872–4.
  51. Halpern MT, Gillespie BW, Warner KE. Patterns of absolute risk of lung cancer mortality in former smokers. J Natl Cancer Inst. 1993;85(6):457–64.
  52. Doll R, Peto R. Mortality in relation to smoking: 20 years’ observations on male British doctors. Br Med J. 1976;2(6051):1525–36.
  53. Doll R, Gray R, Hafner B, Peto R. Mortality in relation to smoking: 22 years’ observations on female British doctors. Br Med J. 1980;280(6219):967–71.
  54. Kreuzer M, Boffetta P, Whitley E, Ahrens W, Gaborieau V, Heinrich J, et al. Gender differences in lung cancer risk by smoking: a multicentre case-control study in Germany and Italy. Br J Cancer. 2000;82(1):227–33.
  55. De Matteis S, Consonni D, Pesatori AC, Bergen AW, Bertazzi PA, Caporaso NE, et al. Are women who smoke at higher risk for lung cancer than men who smoke? Am J Epidemiol. 2013;177(7):601–12.
  56. Yu Y, Liu H, Zheng S, Ding Z, Chen Z, Jin W, et al. Gender susceptibility for cigarette smoking-attributable lung cancer: A systematic review and meta-analysis. Lung Cancer. 2014;85(3):351–60.
  57. Gray N. The consequences of the unregulated cigarette. Tob Control. 2006;15(5):405–8.
  58. Radzikowska E, Głaz P, Roszkowski K. Lung cancer in women: age, smoking, histology, performance status, stage, initial treatment and survival. Population-based study of 20561 cases. Ann Oncol. 2002;13(7):1087–93.
  59. Clarke SW. Aerosols and the Lung: Clinical and Experimental Aspects. Butterworth & Co; 1984.

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