Letter to the Editor

Letter to the Editor

Reduction of radiocesium load: supplementation of Cs versus it's depletion by enterosorbents

DOI: https://doi.org/10.4414/smw.2011.13166
Publication Date: 18.03.2011
Swiss Med Wkly. 2011;141:w13166

Sergei V. Jargin

Peoples’ Friendship University of Russia, Moscow, Russia

In a recently published letter [1], it was noticed that in volume 1181 of The Annals of the New York Academy of Sciences (2009), dedicated to the Chernobyl accident, references to non-professional publications (mass media, websites of unclear affiliation, etc.) were used to back up scientific views. Another theme which was commented on in the letter [1] was the reduction of radiocesium levels in organisms by means of apple pectin used as an enterosorbent. The significant 137Cs-lowering effect of apple pectin in children from radiocontaminated areas, reported by Prof. Nesterenko and co-workers in [2–4], is not immediately understandable because in the studies [3, 4] the children received two teaspoons of diluted pectin-containing apple extract daily, and therefore, consumption of apples and some other fruit and vegetables should have been monitored to render a comparison with the placebo-cohort informative. Pectin is present in many plants (carrots, apricots and others), and is used as a food additive E440 (http://en.wikipedia.org/wiki/Pectin). In the authors’ response an objection was presented: “Taking into account that the quantity of pectin in two teaspoons of powder is equal to the quantity of pectin in 1,500 grams of apples, one should do all his/her best for a piece of apple or pear eaten accidentally and every day for 24 days, to have a significant influence on the objectivity of the experiment.” [5] It should be noted that apple-extract, containing 15–16% of pectin, was given to the children in a daily dose of 10 g [3]. It can be calculated that the concentration of pectin in fresh apples would be, in such case, around 0.1%, whereas according to Wikipedia, a typical level of pectin in fresh apples is 1–1.5% (http://en.wikipedia.org/wiki/Pectin). Moreover, the use of pectin for “decorporation” [2] of 137Cs can be effective only if the level of radiocesium in foodstuff or drinking water is elevated. In the studies [3–4], the children in the sanatorium received only “clean” food. Under such circumstances, an enterosorbent can have an opposite action: if pectin indeed absorbs Cs so efficiently that its level in an organism declines, it might induce compensatory retention by the organism of the whole Cs, including 137Cs accumulated previously when its contents in the environment and foodstuffs was higher (all children came from the contaminated areas). Even if the level of radiocesium in food is elevated but slowly decreasing (like in contaminated areas following a radioactive fallout), reasons for the use of enterosorbents should be questioned, because theoretically it can induce retention of Cs by the organism, including 137Cs accumulated previously (biological half-life of Cs in the human organism is around 60 days [6]). Obviously, it depends on the degree of saturation of the organism with Cs and probably also on potassium, which has similar metabolic pathways [7–9]. Therefore, it is recommended to researchers studying pectin-containing enterosorbents, to verify a hypothesis, according to which Cs supplementation (e.g., by oral intake of cesium chloride [10]) might be more efficient for the purpose of radiocesium washout from the organism than its depletion by enterosorbents: an organism saturated with stable Cs would discharge it together with previously accumulated 137Cs. Considering metabolic similarities between Cs and potassium [7–9], supplementation of the latter for the same purpose could also be evaluated. Effectiveness of either method can be controlled by whole-body dosimetry. A dosimeter must have adequate dose sensitivity throughout the dose range measured [11]. Electrolyte monitoring in blood and urine can be useful as well. When planning such a study, the possible adverse effects of the Cs supplementation [10] should be taken into account.

 

Reply to this Letter to the Editor:
http://www.smw.ch/content/smw-2011-13164/

Correspondence

Correspondence:
Sergei V. Jargin,
Peoples’ Friendship University of Russia

Clementovski per 6-82
Moscow
Russia
sjargin@mail.ru

References

  1 Jargin SV. Overestimation of Chernobyl consequences: poorly substantiated information published. Radiat Environ Biophys. 2010;49:743–5.

  2 Nesterenko VB, Nesterenko AV. 13. Decorporation of Chernobyl radionuclides. Ann N Y Acad Sci. 2009;1181:303–10.

  3 Nesterenko VB, Nesterenko AV, Babenko VI, Yerkovich TV, Babenko IV. Reducing the 137Cs-load in the organism of “Chernobyl” children with apple-pectin. Swiss Med Wkly. 2004;134:24–7.

  4 Bandazhevskaya GS, Nesterenko VB, Babenko VI, Yerkovich TV, Bandazhevsky YI. Relationship between caesium (137Cs) load, cardiovascular symptoms, and source of food in “Chernobyl” children - preliminary observations after intake of oral apple pectin. Swiss Med Wkly. 2004;134:725–9.

  5 Yablokov A, Nesterenko A. Reply to letter by Jargin on “overestimation of Chernobyl consequences: poorly substantiated information published”. Radiat. Environ. Biophys. 2010;49:747–8.

  6 Beentjes LB, Buijs WC, Corstens FH, Duijsings JH. Radioactive contamination of Kiev vacationers after the Chernobyl accident. Biological half-life of Cs. Int J Rad Appl Instrum B. 1988;15(2):171–5.

  7 IARC Ionizing radiation, Part 2. Some internally deposited radionuclides. In: IARC monographies on the evaluation of carcinogenic risks in humans. Lyon: IARC Press; 2001, vol. 78, pp. 342–3.

  8 Mraz FR, JohnsonAM, Patrick H. Metabolism of cesium and potassium in swine as indicated by cesium-134 and potassium-42. J Nutr. 1958;64(4):541–8.

  9 Williams LR, Leggett RW. The distribution of intracellular alkali metals in Reference Man. Phys Med Biol. 1987;32(2):173–90.

10 Melnikov P, Zanoni LZ. Clinical effects of cesium intake. Biol Trace Elem Res. 2010;135(1–3):1–9.

11 Attix FH. Introduction to radiological physics and radiation dosimetry. New York: Wiley; 1986.

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